XPO6 - exportin 6 Gene

Also Known as EXP6; RANBP20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23214

About XPO6

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:28,097,976-28,211,965 (from NCBI)

This gene has 23 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 30.3), spleen (RPKM 24.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

XPO6 Products (2)

mRNA Protein Name
NM_001270940.2 NP_001257869.1 exportin-6 isoform 1
NM_015171.4 NP_055986.1 exportin-6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear export signal receptor activity IDA
IDA: Inferred from direct assay
14592989 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14592989 GOA
Biological Process GO Annotation Evidence References Source
involved in protein export from nucleus IDA
IDA: Inferred from direct assay
14592989 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
28246125 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPO6 Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (32 - 95)

Xpo1

Xpo1: Exportin 1-like protein (103 - 278)

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  • 1125 a.a.
Protein Preferred Names Protein Names

exportin-6

  • ran-binding protein 20

XPO6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
XPO6 Q96QU8 NUP62 Homo sapiens P37198
Y2H
21516116
Intra
XPO6 Q96QU8 NUP62 Homo sapiens P37198
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15892 XPO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20839 Xpo6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27353 Xpo6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta XPO6 VGNC VGNC:97844
Mus musculus XPO6 MGD MGI:2429950
Canis familiaris XPO6 VGNC VGNC:48463
Felis catus XPO6 VGNC VGNC:67114
Bos taurus XPO6 VGNC VGNC:37000
Rattus norvegicus XPO6 RGD RGD:1311491
Others XPO6 NCBI