IFIT3 - interferon induced protein with tetratricopeptide repeats 3 Gene

Homo sapiens

Also known as P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49

Gene ID: 3437 | Gene type: protein coding

About IFIT3

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,327,997-89,340,968 (from NCBI)

This gene has 15 transcripts (splice variants), 522 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 22.6), lung (RPKM 21.1) and 24 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and response to virus. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

IFIT3 Products(4)

mRNA	Protein	Name
NM_001031683.4	NP_001026853.1	interferon-induced protein with tetratricopeptide repeats 3 isoform a
NM_001289758.2	NP_001276687.1	interferon-induced protein with tetratricopeptide repeats 3 isoform b
NM_001289759.2	NP_001276688.1	interferon-induced protein with tetratricopeptide repeats 3 isoform b
NM_001549.6	NP_001540.2	interferon-induced protein with tetratricopeptide repeats 3 isoform a

IFIT3 Protein Structure

TPR_12

TPR_1

TPR_11

TPR_8

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

interferon-induced protein with tetratricopeptide repeats 3

CIG49

Related Diseases

Diseases

Alias

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06563	IFIT3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IFIT3	VGNC	VGNC:73565
Rattus norvegicus	IFIT3	RGD	RGD:1359681
Bos taurus	IFIT3	VGNC	VGNC:30050
Canis familiaris	IFIT3	VGNC	VGNC:51900

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