IFIT3 - interferon induced protein with tetratricopeptide repeats 3 Gene

Also Known as P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3437

About IFIT3

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,327,997-89,340,968 (from NCBI)

This gene has 15 transcripts (splice variants), 522 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 22.6), lung (RPKM 21.1) and 24 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and response to virus. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

IFIT3 Products (4)

mRNA Protein Name
NM_001031683.4 NP_001026853.1 interferon-induced protein with tetratricopeptide repeats 3 isoform a
NM_001289758.2 NP_001276687.1 interferon-induced protein with tetratricopeptide repeats 3 isoform b
NM_001289759.2 NP_001276688.1 interferon-induced protein with tetratricopeptide repeats 3 isoform b
NM_001549.6 NP_001540.2 interferon-induced protein with tetratricopeptide repeats 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
21642987 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
21190939 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17050680 GOA
involved in response to virus IMP
IMP: Inferred from mutant phenotype
21642987 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17050680 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
21813773 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFIT3 Protein Structure

TPR_12

TPR_12: Tetratricopeptide repeat (51 - 124)

TPR_1

TPR_1: Tetratricopeptide repeat (143 - 169)

TPR_11

TPR_11: TPR repeat (243 - 288)

TPR_8

TPR_8: Tetratricopeptide repeat (416 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

interferon-induced protein with tetratricopeptide repeats 3

  • CIG49

IFIT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFIT3 O14879 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra
IFIT3 O14879 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra
IFIT3 O14879 FLJ90650 Homo sapiens Q0P5U8
Y2H Array
25416956
Intra
IFIT3 O14879 FLJ90650 Homo sapiens Q0P5U8
Y2H Prey Pooling
25416956
Intra
IFIT3 O14879 HAUS1 Homo sapiens Q96CS2
Validated Y2H
25416956
Intra
IFIT3 O14879 TMEM183A Homo sapiens Q8IXX5
Y2H Prey Pooling
25416956
Intra
IFIT3 O14879 TMEM183A Homo sapiens Q8IXX5
Pull Down
30833792
Intra
IFIT3 O14879 TMEM183A Homo sapiens Q8IXX5
Validated Y2H
32296183
Intra
IFIT3 O14879 IFIT1B Homo sapiens Q5T764
Anti Tag CoIP
21642987
Intra
IFIT3 O14879 IFIT1B Homo sapiens Q5T764
Validated Y2H
32296183
Intra
IFIT3 O14879 IFIT2 Homo sapiens P09913
Anti Tag CoIP
21642987
Intra
IFIT3 O14879 IFIT2 Homo sapiens P09913
Y2H Array
31515488
Intra
IFIT3 O14879 TPM3 Homo sapiens P06753
Y2H
21516116
Intra
IFIT3 O14879 COPS5 Homo sapiens Q92905
Y2H
17050680
Intra
IFIT3 O14879 COPS5 Homo sapiens Q92905
Anti Tag CoIP
17050680
Intra
IFIT3 O14879 COPS5 Homo sapiens Q92905
Pull Down
17050680
Intra
IFIT3 O14879 IFIT1 Homo sapiens P09914
Y2H Prey Pooling
25416956
Intra
IFIT3 O14879 IFIT1 Homo sapiens P09914
Anti Tag CoIP
21642987
Intra
IFIT3 O14879 IFIT1 Homo sapiens P09914
Y2H Array
31515488
Intra
IFIT3 O14879 IFIT1 Homo sapiens P09914
Validated Y2H
25416956
Intra
IFIT3 O14879 IFIT1 Homo sapiens P09914
Pull Down
30833792
Intra
IFIT3 O14879 IFIT2 Homo sapiens Q8IZ03
Validated Y2H
32296183
Intra
IFIT3 O14879 DEUP1 Homo sapiens Q05D60
Y2H Pooling
16189514
Intra
IFIT3 O14879 DEUP1 Homo sapiens Q05D60
Y2H Prey Pooling
25416956
Intra
IFIT3 O14879 DEUP1 Homo sapiens Q05D60
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lupus Erythematosus

  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Potocki-Shaffer Syndrome

  • Proximal 11p Deletion Syndrome

  • Chromosome 11p11.2 Deletion Syndrome

  • Pss

  • 11p11.2 Deletion

  • P11pds

  • Defect11 Syndrome

  • Deletion Of Chromosome 11p11.2

  • POSHS
Aicardi-Goutieres Syndrome

  • Aicardi Goutieres Syndrome

  • Cree Encephalitis

  • Aicardi-Goutières Syndrome

  • Encephalopathy With Basal Ganglia Calcification

  • Ags

  • Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

  • Pseudotoxoplasmosis Syndrome

  • Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

  • Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

  • Aicardi-Goutieres Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06563 IFIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19206 Ifit3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25694 Ifit3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IFIT3 VGNC VGNC:73565
Rattus norvegicus IFIT3 RGD RGD:1359681
Bos taurus IFIT3 VGNC VGNC:30050
Canis familiaris IFIT3 VGNC VGNC:51900
Others IFIT3 NCBI