IFIT2 - interferon induced protein with tetratricopeptide repeats 2 Gene

Also Known as P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; ISG-54; GARG-39; IFI-54K; ISG-54K; ISG-54 K

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3433

About IFIT2

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,302,046-89,309,271 (from NCBI)

This gene has 15 transcripts (splice variants), 512 orthologues and 4 paralogues. Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues.

Summary

Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

IFIT2 Products (1)

mRNA	Protein	Name
NM_001547.5	NP_001538.4	interferon-induced protein with tetratricopeptide repeats 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19416887	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	19416887	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	19416887	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21190939	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	19416887	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	21642987	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21190939	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21190939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFIT2 Protein Structure

TPR_8

TPR_11

0
100
200
300
400
472 a.a.

Protein Preferred Names	Protein Names
interferon-induced protein with tetratricopeptide repeats 2	Interferon, alpha-inducible protein (MW 54kD)

IFIT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFIT2	P09913	IFIT1	Homo sapiens	P09914	GMS	21642987
Intra	IFIT2	P09913	IFIT1	Homo sapiens	P09914	Anti Tag CoIP	33961781
Intra	IFIT2	P09913	IFIT1	Homo sapiens	P09914	Anti Tag CoIP	21642987
Intra	IFIT2	P09913	IFIT1	Homo sapiens	P09914	Anti Tag CoIP	28514442
Intra	IFIT2	P09913	IFIT3	Homo sapiens	O14879	Anti Tag CoIP	33961781
Intra	IFIT2	P09913	IFIT3	Homo sapiens	O14879	Anti Tag CoIP	28514442
Intra	IFIT2	P09913	IFIT3	Homo sapiens	O14879	Anti Tag CoIP	21642987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06562	IFIT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19692	Ifit2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26187	Ifit2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFIT2	MGD	MGI:99449
Felis catus	IFIT2	VGNC	VGNC:67698
Macaca mulatta	IFIT2	VGNC	VGNC:106062
Canis familiaris	IFIT2	VGNC	VGNC:41877
Rattus norvegicus	IFIT2	RGD	RGD:1307804
Bos taurus	IFIT2	VGNC	VGNC:30049
Others	IFIT2	NCBI