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CENPP - centromere protein P Gene

Also Known as CENP-P

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 401541

About CENPP

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,325,468-92,620,529 (from NCBI)

This gene has 4 transcripts (splice variants) and 165 orthologues. Ubiquitous expression in skin (RPKM 7.8), esophagus (RPKM 2.2) and 24 other tissues.

Summary

CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

CENPP Products (3)

mRNA	Protein	Name
NM_001012267.3	NP_001012267.1	centromere protein P isoform a
NM_001286969.1	NP_001273898.1	centromere protein P isoform b
NM_001286971.1	NP_001273900.1	centromere protein P isoform c

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPP Protein Structure

CENP-P

0
100
200
288 a.a.

Protein Preferred Names	Protein Names
centromere protein P

CENPP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CENPP	Q6IPU0	NHLH1	Homo sapiens	Q5T203	Validated Y2H	25416956
Intra	CENPP	Q6IPU0	NHLH1	Homo sapiens	Q5T203	Y2H Prey Pooling	25416956
Intra	CENPP	Q6IPU0	POLR3K	Homo sapiens	Q9Y2Y1	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	POLR3K	Homo sapiens	Q9Y2Y1	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	POLR3K	Homo sapiens	Q9Y2Y1	Y2H Array	32296183
Intra	CENPP	Q6IPU0	TOX2	Homo sapiens	Q96NM4-3	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	TOX2	Homo sapiens	Q96NM4-3	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	TOX2	Homo sapiens	Q96NM4-3	Y2H Array	32296183
Intra	CENPP	Q6IPU0	ZNF765	Homo sapiens	Q7L2R6-2	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	CENPP	Q6IPU0	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	KLC3	Homo sapiens	Q6P597	Y2H Array	25416956
Intra	CENPP	Q6IPU0	KLC3	Homo sapiens	Q6P597	Y2H Prey Pooling	25416956
Intra	CENPP	Q6IPU0	KLC3	Homo sapiens	Q6P597	Validated Y2H	25416956
Intra	CENPP	Q6IPU0	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	HAUS1	Homo sapiens	Q96CS2	Y2H Array	32296183
Intra	CENPP	Q6IPU0	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	PKNOX2	Homo sapiens	Q96KN3	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	CENPP	Q6IPU0	KIAA1328	Homo sapiens	Q86T90	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	CENPP	Q6IPU0	ATP6V0D2	Homo sapiens	Q8N8Y2	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	NHLH1	Homo sapiens	Q02575	Y2H Array	32296183
Intra	CENPP	Q6IPU0	NHLH1	Homo sapiens	Q02575	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CENPP	Q6IPU0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CENPP	Q6IPU0	CCDC85B	Homo sapiens	Q15834	Y2H Array	32296183
Intra	CENPP	Q6IPU0	CCDC85B	Homo sapiens	Q15834	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	CENPP	Q6IPU0	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	CENPP	Q6IPU0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	CENPP	Q6IPU0	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	TEX11	Homo sapiens	Q8IYF3	Y2H Prey Pooling	25416956
Intra	CENPP	Q6IPU0	TEX11	Homo sapiens	Q8IYF3	Validated Y2H	25416956
Intra	CENPP	Q6IPU0	TEX11	Homo sapiens	Q8IYF3	Y2H Array	25416956
Intra	CENPP	Q6IPU0	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	CENPP	Q6IPU0	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	C2orf88	Homo sapiens	Q9BSF0	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	C2orf88	Homo sapiens	Q9BSF0	Y2H Array	32296183
Intra	CENPP	Q6IPU0	C2orf88	Homo sapiens	Q9BSF0	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	RPIA	Homo sapiens	P49247	Y2H Array	25416956
Intra	CENPP	Q6IPU0	RPIA	Homo sapiens	P49247	Validated Y2H	25416956
Intra	CENPP	Q6IPU0	CENPO	Homo sapiens	Q9BU64	Anti Tag CoIP	33961781
Intra	CENPP	Q6IPU0	CENPO	Homo sapiens	Q9BU64	Anti Tag CoIP	28514442
Intra	CENPP	Q6IPU0	CENPO	Homo sapiens	Q9BU64	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	CENPO	Homo sapiens	Q9BU64	Y2H Array	32296183
Intra	CENPP	Q6IPU0	CENPO	Homo sapiens	Q9BU64	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	CENPP	Q6IPU0	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	CENPP	Q6IPU0	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	CENPP	Q6IPU0	ZNF341	Homo sapiens	Q9BYN7	Y2H Prey Pooling	25416956
Intra	CENPP	Q6IPU0	ZNF341	Homo sapiens	Q9BYN7	Validated Y2H	25416956
Intra	CENPP	Q6IPU0	ZNF341	Homo sapiens	Q9BYN7	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intervertebral Disc Disease	Lumbar Disc Disease Intervertebral Disc Disorder IDD Lumbar Disc Herniation Lumbar Disc Degeneration Intervertebral Disc Disease, Susceptibility To Lumbar Disc Herniation, Susceptibility To Lumbar Disc Disease, Susceptibility To Intervertebral Disc Degeneration Discogenic Disease Discogenic Disorder Disorder Of Intervertebral Disc Intervertebral Disk Degeneration Intervertebral Disk Disease Ldd Ldh Lumbar Disc Degeneration, Susceptibility To Degeneration Of Lumbar Intervertebral Disc Intervertebral Disk Displacement

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02488	CENPP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CENPP	VGNC	VGNC:102912
Rattus norvegicus	CENPP	RGD	RGD:1589530
Canis familiaris	CENPP	VGNC	VGNC:39111
Bos taurus	CENPP	VGNC	VGNC:59195
Mus musculus	CENPP	MGD	MGI:1913586
Macaca mulatta	CENPP	VGNC	VGNC:97750
Others	CENPP	NCBI