SF3B3 - splicing factor 3b subunit 3 Gene

Also Known as RSE1; SAP130; SF3b130; STAF130

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23450

About SF3B3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,523,816-70,577,668 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 13.7), lymph node (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (Histone Acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

SF3B3 Products (1)

mRNA Protein Name
NM_012426.5 NP_036558.3 splicing factor 3B subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17332742 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11564863 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
27720643 GOA
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
23951410 GOA
Cellular Component GO Annotation Evidence References Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of U2-type spliceosomal complex IPI
IPI: Inferred from physical interaction
27720643 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27720643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B3 Protein Structure

MMS1_N

MMS1_N: Mono-functional DNA-alkylating methyl methanesulfonate N-term (76 - 592)

CPSF_A

CPSF_A: CPSF A subunit region (863 - 1183)

  • 0
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  • 1000
  • 1217 a.a.
Protein Preferred Names Protein Names

splicing factor 3B subunit 3

  • SAP 130

SF3B3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SF3B3 Q15393 SF3A3 Homo sapiens Q12874
Anti Tag CoIP
35271311
Intra
SF3B3 Q15393 SF3A3 Homo sapiens Q12874
Crosslink
30021884
Intra
SF3B3 Q15393 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Cross: Cross-species interaction Intra: Intraspecies interaction

SF3B3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81426 SF3B3 Antibody (YA1171) IHC-P Human
HY-P81426A SF3B3 Antibody (YA1171)(PBS only) IHC-P Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12762 SF3B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20489 Sf3b3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26997 Sf3b3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SF3B3 VGNC VGNC:77181
Bos taurus SF3B3 VGNC VGNC:34511
Felis catus SF3B3 VGNC VGNC:65057
Rattus norvegicus SF3B3 RGD RGD:1311636
Mus musculus SF3B3 MGD MGI:1289341
Canis familiaris SF3B3 VGNC VGNC:46071
Others SF3B3 NCBI