PNN - pinin, desmosome associated protein Gene

Also Known as DRS; DRSP; SDK3; memA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5411

About PNN

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:39,175,254-39,183,220 (from NCBI)

This gene has 6 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in bone marrow (RPKM 45.1), lymph node (RPKM 42.9) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in nuclear speck. Part of catalytic step 2 spliceosome. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

PNN Products (1)

mRNA Protein Name
NM_002687.4 NP_002678.3 pinin

PNN Protein Structure

Pinin_SDK_N

Pinin_SDK_N: pinin/SDK conserved region (1 - 133)

Pinin_SDK_memA

Pinin_SDK_memA: pinin/SDK/memA/ protein conserved region (134 - 264)

  • 0
  • 200
  • 400
  • 600
  • 717 a.a.
Protein Preferred Names Protein Names

pinin

  • 140 kDa nuclear and cell adhesion-related phosphoprotein

PNN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PNN Q9H307 SAP18 Homo sapiens O00422
Anti Tag CoIP
33961781
Intra
PNN Q9H307 SAP18 Homo sapiens O00422
Anti Tag CoIP
22388736
Intra
PNN Q9H307 RNPS1 Homo sapiens Q15287-1
GMS
22388736
Intra
PNN Q9H307 RNPS1 Homo sapiens Q15287-1
Pull Down
22388736
Intra
PNN Q9H307 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
PNN Q9H307 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
PNN Q9H307 ACIN1 Homo sapiens Q9UKV3
Anti Tag CoIP
33961781
Intra
PNN Q9H307 ACIN1 Homo sapiens Q9UKV3
Anti Tag CoIP
28514442
Intra
PNN Q9H307 ACIN1 Homo sapiens Q9UKV3
Crosslink
30021884
Intra
PNN Q9H307 SNW1 Homo sapiens Q13573
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

PNN Antibodies

Cat. No. Product Name Application Reactivity
HY-P811152 Pinin Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10786 PNN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20243 Pnn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26751 Pnn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PNN MGD MGI:1100514
Bos taurus PNN VGNC VGNC:33087
Rattus norvegicus PNN RGD RGD:1597086
Canis familiaris PNN VGNC VGNC:44748
Others PNN NCBI