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SF3B5 - splicing factor 3b subunit 5 Gene

Also Known as Ysf3; SF3b10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83443

About SF3B5

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:144,094,884-144,095,573 (from NCBI)

This gene has 1 transcript (splice variant) and 208 orthologues.

Summary

Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

SF3B5 Products (1)

mRNA	Protein	Name
NM_031287.3	NP_112577.1	splicing factor 3B subunit 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	27720643	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA
enables splicing factor binding	IDA IDA: Inferred from direct assay	27720643	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	27720643	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U2-type spliceosomal complex	IPI IPI: Inferred from physical interaction	27720643	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27720643	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B5 Protein Structure

SF3b10

0
86 a.a.

Protein Preferred Names	Protein Names
splicing factor 3B subunit 5	pre-mRNA-splicing factor SF3b 10 kDa subunit

SF3B5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SF3B5	Q9BWJ5	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12764	SF3B5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SF3B5	MGD	MGI:1913375
Canis familiaris	SF3B5	VGNC	VGNC:46073
Bos taurus	SF3B5	VGNC	VGNC:34512
Felis catus	SF3B5	VGNC	VGNC:65059
Rattus norvegicus	SF3B5	RGD	RGD:1586993
Others	SF3B5	NCBI