SF3B6 - splicing factor 3b subunit 6 Gene

Also Known as P14; Ht006; SAP14; SAP14a; SF3B14; CGI-110; HSPC175; SF3B14a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51639

About SF3B6

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,067,586-24,076,326 (from NCBI)

This gene has 2 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in bone marrow (RPKM 53.9), colon (RPKM 39.5) and 25 other tissues.

Summary

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]

SF3B6 Products (1)

mRNA Protein Name
NM_016047.4 NP_057131.1 splicing factor 3B subunit 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
16432215 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16432215 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
27720643 GOA
Cellular Component GO Annotation Evidence References Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of U2-type spliceosomal complex IPI
IPI: Inferred from physical interaction
27720643 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27720643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B6 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (21 - 87)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

splicing factor 3B subunit 6

  • SF3b 14 kDa subunit

SF3B6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SF3B6 Q9Y3B4 SF3B1 Homo sapiens O75533-1
X-Ray Diffraction
16432215
Intra
SF3B6 Q9Y3B4 SF3B1 Homo sapiens O75533-1
GMS
16432215
Intra
SF3B6 Q9Y3B4 SF3B1 Homo sapiens O75533-1
Pull Down
16432215
Intra
SF3B6 Q9Y3B4 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
35271311
Intra
SF3B6 Q9Y3B4 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra
SF3B6 Q9Y3B4 SF3B1 Homo sapiens O75533
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12765 SF3B6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SF3B6 VGNC VGNC:97825
Mus musculus SF3B6 MGD MGI:1913305
Bos taurus SF3B6 VGNC VGNC:34513
Rattus norvegicus SF3B6 RGD RGD:2318878
Canis familiaris SF3B6 VGNC VGNC:46074
Felis catus SF3B6 VGNC VGNC:81219
Others SF3B6 NCBI