EP39
EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity.
For research use only. We do not sell to patients.
- Formula: C38H62N2O5
- Molecular Weight:626.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EP39 has binding affinity to different residues of SP1. SP1-T239 has the highest binding affinity (52.4 μM); SP1-S236, SP1-Q237 and SP1-V238 have relatively high binding affinities (179.6 μM, 154,5 μM and 204.4 μM, respectively); SP1-E233, SP1-M235 and NC-T257 have medium binding affinities (237.0 μM, 235,4 μM, 308.4 μM, respectively); CA-V221, CA-L231 and SP1-A232 have weak binding affinities (669.6 μM, 678.4 μM and 691.9 μM, respectively) [1].
EP39 perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 626.91
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Formula C38H62N2O5
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SMILES
NCCNC([C@]12C([C@@H](CC2)C(C)=C)C3[C@@](CC1)([C@]4(C([C@@]5(C(C(C)([C@H](CC5)OC(CC(C)(C)C(O)=O)=O)C)CC4)C)CC3)C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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