FGF-12
FGF-12 (FHF2) is the second member of the intracrine FGF homologous factor group. Like its subgroup relatives it carries no signal peptide and does not act as a classical secreted FGFR ligand; instead it binds voltage-gated sodium channels in neurons and cardiomyocytes and modulates their gating. FGF12 is enriched in brain, heart and sensory neurons. Gain-of-function variants in FGF12 cause early-infantile epileptic encephalopathy, while reduced FHF2 function in mouse heart reproduces aspects of Brugada syndrome. Recombinant FGF-12 supports patch-clamp studies of sodium channel regulation, epilepsy variant characterization and protein-interaction work on FHF complexes.
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FGF-12 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
