DYNC2I2 - dynein 2 intermediate chain 2 Gene

Also Known as DIC5; WDR34; FAP133; SRTD11; CFAP133; bA216B9.3

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 89891

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]

DYNC2I2 Products (1)

mRNA Protein Name
XM_011519179.3 XP_011517481.1 cytoplasmic dynein 2 intermediate chain 2 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables dynein light chain binding IPI
IPI: Inferred from physical interaction
25830415 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cilium assembly IGI
IGI: Inferred from genetic interaction
25205765 GOA
involved in intraciliary retrograde transport IMP
IMP: Inferred from mutant phenotype
29742051 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in centrosome IDA
IDA: Inferred from direct assay
25205765 GOA
located in ciliary basal body IDA
IDA: Inferred from direct assay
25205765 GOA
located in cilium IDA
IDA: Inferred from direct assay
25205765 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
25205765 GOA
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
25205765 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic dynein 2 intermediate chain 2

  • WD repeat domain 34

  • WD repeat-containing protein 34

DYNC2I2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DYNC2I2 Q96EX3 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
DYNC2I2 Q96EX3 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
DYNC2I2 Q96EX3 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
DYNC2I2 Q96EX3 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra
DYNC2I2 Q96EX3 DYNC2I1 Homo sapiens Q8WVS4
TAP
27173435
Intra
DYNC2I2 Q96EX3 COIL Homo sapiens P38432
Y2H Array
25416956
Intra
DYNC2I2 Q96EX3 COIL Homo sapiens P38432
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04084 DYNC1I2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown