DYNC2I1 - dynein 2 intermediate chain 1 Gene

Also Known as DIC6; SRPS6; SRTD8; WDR60; FAP163; CFAP163

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 55112

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, Apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]

DYNC2I1 Products (1)

mRNA Protein Name
XM_054358568.1 XP_054214543.1 cytoplasmic dynein 2 intermediate chain 1 isoform X10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables dynein light chain binding IPI
IPI: Inferred from physical interaction
25830415 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cilium assembly IGI
IGI: Inferred from genetic interaction
25205765 GOA
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
23910462 GOA
involved in embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
23910462 GOA
involved in intraciliary retrograde transport IDA
IDA: Inferred from direct assay
29742051 GOA
Cellular Component GO Annotation Evidence Verweise Source
colocalizes with centrosome IDA
IDA: Inferred from direct assay
25830415 GOA
located in centrosome IDA
IDA: Inferred from direct assay
31451806 GOA
colocalizes with ciliary base IDA
IDA: Inferred from direct assay
25830415 GOA
located in ciliary base IDA
IDA: Inferred from direct assay
23910462 GOA
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
25205765 GOA
colocalizes with interphase microtubule organizing center IDA
IDA: Inferred from direct assay
25830415 GOA
located in pericentriolar material IDA
IDA: Inferred from direct assay
25205765 GOA
colocalizes with spindle pole IDA
IDA: Inferred from direct assay
25830415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic dynein 2 intermediate chain 1

  • WD repeat domain 60

  • WD repeat-containing protein 60

  • testicular secretory protein Li 66

DYNC2I1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DYNC2I1 Q8WVS4 DYNC2I2 Homo sapiens Q96EX3
GMS
31451806
Intra
DYNC2I1 Q8WVS4 DYNC2I2 Homo sapiens Q96EX3
Anti Tag CoIP
33961781
Intra
DYNC2I1 Q8WVS4 DYNC2I2 Homo sapiens Q96EX3
3D-EM-Single
31451806
Intra
DYNC2I1 Q8WVS4 DYNC2I2 Homo sapiens Q96EX3
TAP
27173435
Intra
DYNC2I1 Q8WVS4 NUDC Homo sapiens Q9Y266
TAP
27173435
Intra
DYNC2I1 Q8WVS4 NUDC Homo sapiens Q9Y266
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04083 DYNC1I1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04086 DYNC2H1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04087 DYNC2LI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown