PDE4D - phosphodiesterase 4D Gene

Also Known as DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5144

About PDE4D

Cytogenetic location: 5q11.2-q12.1 Genomic coordinates (GRCh38): 5:58,969,038-60,522,128 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues, 20 paralogues and is associated with 5 phenotypes. Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues.

Summary

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

PDE4D Products (18)

mRNA	Protein	Name
NM_001104631.2	NP_001098101.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4
NM_001165899.2	NP_001159371.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7
NM_001197218.2	NP_001184147.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D5
NM_001197219.2	NP_001184148.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D8
NM_001197220.2	NP_001184149.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D9
NM_001197221.2	NP_001184150.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2
NM_001197222.2	NP_001184151.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D1
NM_001197223.2	NP_001184152.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D6
NM_001349241.2	NP_001336170.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 10
NM_001349242.2	NP_001336171.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 11
NM_001349243.2	NP_001336172.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12
NM_001364599.1	NP_001351528.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7
NM_001364600.2	NP_001351529.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 14
NM_001364601.1	NP_001351530.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 15
NM_001364602.2	NP_001351531.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 16
NM_001364603.1	NP_001351532.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2
NM_001364604.1	NP_001351533.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12
NM_006203.5	NP_006194.2	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	9371713	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IGI IGI: Inferred from genetic interaction	8413254	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	21903937	GOA
enables cAMP binding	IDA IDA: Inferred from direct assay	9371713	GOA
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	9371713	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17620599	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	15182229	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16213210	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	12121997	GOA
involved in cellular response to epinephrine stimulus	IDA IDA: Inferred from direct assay	12121997	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	20819076	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19252089	GOA
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	16213210	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	16213210	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9371713	GOA
NOT located in membrane	IDA IDA: Inferred from direct assay	9371713	GOA
located in membrane	IDA IDA: Inferred from direct assay	9371713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE4D Protein Structure

PDEase_I

0
200
400
600
809 a.a.

Protein Preferred Names	Protein Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	cAMP-specific phosphodiesterase PDE4D6

PDE4D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDE4D	Q08499	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	PDE4D	Q08499	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Array	25416956
Intra	PDE4D	Q08499	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Prey Pooling	25416956
Intra	PDE4D	Q08499	GOLGA8DP	Homo sapiens	Q0D2H9	Validated Y2H	25416956
Intra	PDE4D	Q08499	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	PDE4D	Q08499	PDE4B	Homo sapiens	Q07343	Anti Tag CoIP	33961781
Intra	PDE4D	Q08499	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	PDE4D	Q08499	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	PDE4D	Q08499	COIL	Homo sapiens	P38432	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PDE4D Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81969	PDE4D Antibody (YA1714)	WB	Human

Related Diseases

Diseases	Alias
Acrodysostosis 2 With Or Without Hormone Resistance	ACRDYS2 Acrodysostosis 2, With Or Without Hormone Resistance Acrodysostosis, With/Without Hormone Resistance, Type 2 Acrodysostosis
Acrodysostosis With Multiple Hormone Resistance
Acrodysostosis	Acrodysplasia Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Chromosome 5q12 Deletion Syndrome	Pde4d Haploinsufficiency Syndrome
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Ocular Hypotension	Hypotony Of Eye
Spinal Stenosis	Lumbar Spinal Stenosis Cervical Spinal Stenosis Spinal Stenosis Of Lumbar Region Spinal Stenosis In Cervical Region Spinal Canal Stenosis
Brachydactyly
Hypertension And Brachydactyly Syndrome	Brachydactyly With Hypertension Bilginturan Syndrome HTNB Brachydactyly-Arterial Hypertension Syndrome Brachydactyly, Type E, With Short Stature And Hypertension Bilginturan Brachydactyly Brachydactyly Type E With Short Stature And Hypertension Type E Brachydactyly With Short Stature And Hypertension Brachydactyly Type E, With Short Stature And Hypertension Hypertension With Brachydactyly
Hypothyroidism, Congenital, Nongoitrous, 1	Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Thyroid-Stimulating Hormone Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome
Pseudohypoparathyroidism, Type Ia	Albright'S Hereditary Osteodystrophy Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a PHP1A Albright Hereditary Osteodystrophy With Multiple Hormone Resistance Pseudohypoparathyroidism Ia AHO Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy Pseudo-Pseudohypoparathyroidism Pseudohypoparathyroidism Type I A Php Ia Pseudopseudohypoparathyroidism Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Pphp Pseudopseudo-Hypoparathyroidism Aho-Php Syndrome Ia Albright Hereditary Osteodystrophy-Php Syndrome Ia Pseudohypoparathyroidism 1a Pseudohypoparathyroidism
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Pseudopseudohypoparathyroidism	PPHP Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Normocalcemic Pseudohypoparathyroidism Aho-Pphp Syndrome Albright Hereditary Osteodystrophy-Pphp Syndrome Pseudohypoparathyroidism
Chondrodysplasia, Blomstrand Type	Chondrodysplasia Blomstrand Type BOCD Blomstrand Lethal Chondrodysplasia Blomstrand Lethal Osteochondrodysplasia Blomstrand'S Lethal Chondrodysplasia Blc Blomstrand Chondrodysplasia Blomstrand Osteochondrodysplasia
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Chromosome 2q37 Deletion Syndrome	Albright Hereditary Osteodystrophy-Like Syndrome 2q37 Microdeletion Syndrome Brachydactyly-Intellectual Disability Syndrome Deletion 2q37 2q37 Deletion Syndrome Brachydactyly-Mental Retardation Syndrome Bdmr Albright Hereditary Osteodystrophy Type 3 Del(2)(Q37) Monosomy 2q37qter Albright'S Hereditary Osteodystrophy-Like Syndrome Monosomy 2q37 Chromosome Deletion Syndrome 2q37
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Pseudohypoparathyroidism, Type Ib	Pseudohypoparathyroidism Type 1b PHP1B Pseudohypoparathyroidism Ib Pseudohypoparathyroidism Type Ib Php Ib Pseudohypoparathyroidism 1b
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117571	Zatolmilast	Inhibitor	99.50%	Phase 3
HY-117960	Orismilast	Inhibitor	99.88%	Phase 2
HY-15178	Oglemilast	Inhibitor	99.97%	Phase 2
HY-108047	MK-0873	Inhibitor	95.0%	Phase 2
HY-111167	AN-2898	Inhibitor	/	Phase 2
HY-106003	GSK356278	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122942	Moracin M		98.99%	Unkown
HY-15444	D159687	Inhibitor	98.42%	Unkown
HY-128358	MR-L2	Activator	98.63%	Unkown
HY-115687	PDE4B-IN-2	Inhibitor	99.59%	Unkown
HY-119190	PF-06445974	Inhibitor	98.59%	Unkown
HY-16900A	(R)-(-)-Rolipram	Inhibitor	99.91%	Unkown
HY-103050	ML-030	Inhibitor	99.28%	Unkown
HY-139178	KVA-D-88	Inhibitor	99.81%	Unkown
HY-155830	Morcamilast	Inhibitor	98.92%	Unkown
HY-100246	CI-1044	Inhibitor	98.02%	Unkown
HY-169981	PDE4-IN-24	Inhibitor	99.44%	Unkown
HY-131707	LEO 39652	Inhibitor	99.51%	Unkown
HY-117977	FCPR03	Inhibitor	99.82%	Unkown
HY-121037	Eggmanone	Inhibitor	95.31%	Unkown
HY-161772	(S)-Gebr32a	Inhibitor	98.97%	Unkown
HY-RS10225	PDE4D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-112704	PDE5-IN-2	Inhibitor	/	Unkown
HY-130262	PDE1-IN-3	Inhibitor	/	Unkown
HY-114052	NVP-ABE171	Inhibitor	/	Unkown
HY-115913	PDE4-IN-6	Inhibitor	/	Unkown
HY-120945	PDE10A-IN-1	Inhibitor	/	Unkown
HY-121041	GEBR-7b		/	Unkown
HY-147846	AChE/PDE4-IN-1	Inhibitor	/	Unkown
HY-14918	Catramilast	Inhibitor	/	Unkown
HY-154957	mTOR inhibitor-11	Inhibitor	/	Unkown
HY-159654	PDE4-IN-19	Inhibitor	/	Unkown
HY-161936	Z21115	Inhibitor	/	Unkown
HY-162582	Z19153	Inhibitor	/	Unkown
HY-162583	PDE4-IN-17	Inhibitor	/	Unkown
HY-168558	PDE4B/D-IN-4	Inhibitor	/	Unkown
HY-170397	ADORA2A/PDE4D-IN-1		/	Unkown
HY-172776	Phosphodiesterase-IN-3	Inhibitor	/	Unkown
HY-173290	PDE4D inhibitor 1	Inhibitor	/	Unkown
HY-176234	PDE4-IN-28	Inhibitor	/	Unkown
HY-176520	PDE4-IN-29	Inhibitor	/	Unkown
HY-179407	LT-104A	Inhibitor	/	Unkown
HY-180803	LH17	Inhibitor	/	Unkown
HY-181549	PDE4-IN-32	Inhibitor	/	Unkown
HY-181646	PDE4-IN-34	Inhibitor	/	Unkown
HY-181774	PDE4/5-IN-1	Inhibitor	/	Unkown
HY-182060	PDE4B/D-IN-5		/	Unkown
HY-201403	LY2775240	Inhibitor	/	Unkown
HY-119799	UK-500001	Inhibitor	/	Unkown
HY-RS17612	Pde4d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24072	Pde4d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDE4D	VGNC	VGNC:32677
Felis catus	PDE4D	VGNC	VGNC:68759
Macaca mulatta	PDE4D	VGNC	VGNC:75917
Canis familiaris	PDE4D	VGNC	VGNC:44355
Rattus norvegicus	PDE4D	RGD	RGD:3281
Mus musculus	PDE4D	MGD	MGI:99555
Others	PDE4D	NCBI