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Cat. No.: HY-181774

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PDE4/5-IN-1

PDE4/5-IN-1 is a selective phosphodiesterase 4/5 (PDE4/5) dual inhibitor. PDE4/5-IN-1 functionally inhibits PDE5, PDE4B2, and PDE4D2 activity. PDE4/5-IN-1 relaxes isolated rat prostate tissue, enhances nitric oxide-induced relaxation in isolated rat prostate tissue, and reduces alpha-1 adrenoceptor-mediated contractile responses in isolated rat prostate tissue. PDE4/5-IN-1 inhibits proliferation of human hyperplastic prostate cells. PDE4/5-IN-1 can be used for the research of benign prostatic hyperplasia.

For research use only. We do not sell to patients.

CAS No.: 1807631-43-1
Formula: C₂₃H₁₉N₃O₆
Molecular Weight:433.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PDE4/5-IN-1 Chemical Structure

CAS No.: 1807631-43-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PDE4B2

PDE4D2

PDE5

PDE6

PDE11

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE4/5-IN-1 (Compound VIII) (1-10 μM) exhibits dual inhibitory activity against PDE4 (specifically PDE4B2 and PDE4D2) and PDE5 enzymes at 1 μM, and also inhibits PDE6 and PDE11 enzymes at 10 μM in cell-free assays^[1].
PDE4/5-IN-1 (0.003 μM-3 μM) significantly inhibits the proliferation of RWPE-1, BPH-1, and WPMY-1 human prostate cell lines, with the strongest effect in WPMY-1 stromal cells^[1].
PDE4/5-IN-1 (3 μM) significantly potentiates SNP (HY-B0564)-induced relaxation and reduces alpha-1 adrenoceptor-mediated contractile responses in rat prostatic tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1807631-43-1
Molecular Weight 433.41
Formula C₂₃H₁₉N₃O₆
SMILES

O=C1CN(CCO)C(C2=C(C3=CNC4=C3C=CC=C4)OC(C5=CC=C(OCO6)C6=C5)N21)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Helfstein DR, et al. Synthesis and Pharmacological Evaluation of 6,7-Dihydro‑3H‑Oxazolo[3,4‑a]Pyrazine-5,8-Dione Compounds as Inhibitors of Phosphodiesterases 4 and 5. ACS Med Chem Lett. 2026;17(2):341-350. Published 2026 Jan 20. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PDE4/5-IN-1

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PDE4/5-IN-1 Related Classifications

HY-181774 Related Classifications