1807631-43-1
Chemical Structure
PDE4/5-IN-1
- CAS No.: 1807631-43-1
- Formula:C23H19N3O6
- Molecular Weight:433.41
InChIKey: CAHPIQOOVPQPKR-UHFFFAOYSA-N
SMILES: O=C1CN(CCO)C(C2=C(C3=CNC4=C3C=CC=C4)OC(C5=CC=C(OCO6)C6=C5)N21)=O
Biological Activity: PDE4/5-IN-1 is a selective phosphodiesterase 4/5 (PDE4/5) dual inhibitor. PDE4/5-IN-1 functionally inhibits PDE5, PDE4B2, and PDE4D2 activity. PDE4/5-IN-1 relaxes isolated rat prostate tissue, enhances nitric oxide-induced relaxation in isolated rat prostate tissue, and reduces alpha-1 adrenoceptor-mediated contractile responses in isolated rat prostate tissue. PDE4/5-IN-1 inhibits proliferation of human hyperplastic prostate cells. PDE4/5-IN-1 can be used for the research of benign prostatic hyperplasia[1].
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PDE4/5-IN-1 | PDE4/5-IN-1 is a selective phosphodiesterase 4/5 (PDE4/5) dual inhibitor. PDE4/5-IN-1 functionally inhibits PDE5, PDE4B2, and PDE4D2 activity. PDE4/5-IN-1 relaxes isolated rat prostate tissue, enhances nitric oxide-induced relaxation in isolated rat prostate tissue, and reduces alpha-1 adrenoceptor-mediated contractile responses in isolated rat prostate tissue. PDE4/5-IN-1 inhibits proliferation of human hyperplastic prostate cells. PDE4/5-IN-1 can be used for the research of benign prostatic hyperplasia. | |||||||||||||||||||||
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