LH17
LH17, a Kaempferol (HY-14590) derivative, is a potent and selective PDE4 inhibitor (PDE4D2 IC50 = 73 nM, PDE4B2 IC50 = 190 nM). LH17 exhibits remarkable selectivity (>136-fold) against other PDE isoforms (PDE1B/2A/3A/5A/8A/9A/10A) (IC50 > 10000 nM), with the exception of PDE7A1 (IC50 = 300 nM). LH17 distinctly interacts with PDE4 M-pocket. LH17 demonstrates remarkable anti-fibrotic efficacy in both in vitro and in vivo models. LH17 can be used for idiopathic pulmonary fibrosis (IPF) research.
For research use only. We do not sell to patients.
- Formula: C28H25NO6
- Molecular Weight:471.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
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PDE4D2 73 nM (IC50) |
PDE4B2 190 nM (IC50) |
PDE7A1 300 nM (IC50) |
PDE1B2 >10000 nM (IC50) |
PDE2A >10000 nM (IC50) |
PDE3A >10000 nM (IC50) |
PDE5A1 >10000 nM (IC50) |
PDE7A1 >10000 nM (IC50) |
PDE8A1 >10000 nM (IC50) |
PDE9A1 >10000 nM (IC50) |
PDE10A1 >10000 nM (IC50) |
Chemical Information
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Molecular Weight 471.50
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Formula C28H25NO6
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SMILES
CC1(C)OC2=CC3=C(C(C(OC)=C(C4=CC=C(OC)C=C4)O3)=O)C(OCC5=CC=NC=C5)=C2C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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