2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. LH17

LH17, a Kaempferol (HY-14590) derivative, is a potent and selective PDE4 inhibitor (PDE4D2 IC50 = 73 nM, PDE4B2 IC50 = 190 nM). LH17 exhibits remarkable selectivity (>136-fold) against other PDE isoforms (PDE1B/2A/3A/5A/8A/9A/10A) (IC50 > 10000 nM), with the exception of PDE7A1 (IC50 = 300 nM). LH17 distinctly interacts with PDE4 M-pocket. LH17 demonstrates remarkable anti-fibrotic efficacy in both in vitro and in vivo models. LH17 can be used for idiopathic pulmonary fibrosis (IPF) research.

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LH17

LH17 Chemical Structure

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LH17 Related Antibodies

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Description

LH17, a Kaempferol (HY-14590) derivative, is a potent and selective PDE4 inhibitor (PDE4D2 IC50 = 73 nM, PDE4B2 IC50 = 190 nM). LH17 exhibits remarkable selectivity (>136-fold) against other PDE isoforms (PDE1B/2A/3A/5A/8A/9A/10A) (IC50 > 10000 nM), with the exception of PDE7A1 (IC50 = 300 nM). LH17 distinctly interacts with PDE4 M-pocket. LH17 demonstrates remarkable anti-fibrotic efficacy in both in vitro and in vivo models. LH17 can be used for idiopathic pulmonary fibrosis (IPF) research[1].

IC50 & Target[1]

PDE4D2

73 nM (IC50)

PDE4B2

190 nM (IC50)

PDE7A1

300 nM (IC50)

PDE1B2

>10000 nM (IC50)

PDE2A

>10000 nM (IC50)

PDE3A

>10000 nM (IC50)

PDE5A1

>10000 nM (IC50)

PDE7A1

>10000 nM (IC50)

PDE8A1

>10000 nM (IC50)

PDE9A1

>10000 nM (IC50)

PDE10A1

>10000 nM (IC50)

Molecular Weight

471.50

Formula

C28H25NO6
SMILES

CC1(C)OC2=CC3=C(C(C(OC)=C(C4=CC=C(OC)C=C4)O3)=O)C(OCC5=CC=NC=C5)=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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LH17 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LH17LH 17LH-17Phosphodiesterase (PDE)PDE4anti-fibrotic efficacyidiopathic pulmonary fibrosisInhibitorinhibitorinhibit

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