1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. (R)-(-)-Rolipram

(R)-(-)-Rolipram (Synonyms: (R)-Rolipram; (-)-Rolipram)

Cat. No.: HY-16900A Purity: 99.91%
Handling Instructions

(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

For research use only. We do not sell to patients.

(R)-(-)-Rolipram Chemical Structure

(R)-(-)-Rolipram Chemical Structure

CAS No. : 85416-75-7

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10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of (R)-(-)-Rolipram:

Top Publications Citing Use of Products

Publications Citing Use of MCE (R)-(-)-Rolipram

    (R)-(-)-Rolipram purchased from MCE. Usage Cited in: Immunity. 2016 Oct 18;45(4):944.

    LPS-primed BMDMs are treated with different doses of (R)-(-)-Rolipram, and then stimulated with Nigericin for 45 min. Supernatants (SN) and cell extracts (Lysate) are analyzed by immunoblotting. The phosphodiesterase inhibitors isobutylmethylxanthine (IBMX) and (R)-(-)-rolipram suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner.
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    Description

    (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

    In Vitro

    The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1].

    Molecular Weight

    275.34

    Formula

    C₁₆H₂₁NO₃

    CAS No.

    85416-75-7

    SMILES

    O=C1NC[[email protected]@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 49 mg/mL (177.96 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6319 mL 18.1594 mL 36.3187 mL
    5 mM 0.7264 mL 3.6319 mL 7.2637 mL
    10 mM 0.3632 mL 1.8159 mL 3.6319 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.91%

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    Keywords:

    (R)-(-)-Rolipram(R)-Rolipram(-)-RolipramPhosphodiesterase (PDE)Inhibitorinhibitorinhibit

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    Product Name:
    (R)-(-)-Rolipram
    Cat. No.:
    HY-16900A
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