Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1

  • Bioorg Med Chem Lett. 2006 Jul 1;16(13):3430-3. doi: 10.1016/j.bmcl.2006.04.012.
Baogen Wu  1 ,  Kelli Kuhen ,  Truc Ngoc Nguyen ,  David Ellis ,  Beth Anaclerio ,  Xiaohui He ,  Kunyong Yang ,  Donald Karanewsky ,  Hong Yin ,  Karen Wolff ,  Kimberly Bieza ,  Jeremy Caldwell ,  Yun He
Affiliations
  • 1. Genomics Institute of the Novartis Research Foundation, GNF, 10675 John Jay Hopkins Dr. San Diego, CA 92121, USA. [email protected]
PMID: 16632349 DOI: 10.1016/j.bmcl.2006.04.012
Abstract

The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside Reverse Transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).