1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Oglemilast

Oglemilast (Synonyms: GRC 3886)

Cat. No.: HY-15178 Purity: 96.83%
Handling Instructions

Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.

For research use only. We do not sell to patients.

Oglemilast Chemical Structure

Oglemilast Chemical Structure

CAS No. : 778576-62-8

Size Price Stock Quantity
5 mg USD 182 In-stock
Estimated Time of Arrival: December 31
10 mg USD 307 In-stock
Estimated Time of Arrival: December 31
50 mg USD 612 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma. IC50 value: Target: PDE4

Clinical Trial
Molecular Weight

516.30

Formula

C₂₀H₁₃Cl₂F₂N₃O₅S

CAS No.

778576-62-8

SMILES

O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (7.75 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9369 mL 9.6843 mL 19.3686 mL
5 mM 0.3874 mL 1.9369 mL 3.8737 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.4 mg/mL (0.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Oglemilast
Cat. No.:
HY-15178
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