1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Oglemilast

Oglemilast (Synonyms: GRC 3886)

Cat. No.: HY-15178 Purity: 98.20%
Handling Instructions

Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.

For research use only. We do not sell to patients.

Oglemilast Chemical Structure

Oglemilast Chemical Structure

CAS No. : 778576-62-8

Size Price Stock Quantity
5 mg USD 182 In-stock
Estimated Time of Arrival: December 31
10 mg USD 307 In-stock
Estimated Time of Arrival: December 31
50 mg USD 612 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases[1][2][3].

IC50 & Target

PDE4D3

0.5 nM (IC50)

In Vitro

Oglemilast (GRC 3886) has EC50s of 11.4 nM, 4.4 nM for PDE 4B1 and PDE 4D3 reporter cell lines, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

516.30

Formula

C₂₀H₁₃Cl₂F₂N₃O₅S

CAS No.
SMILES

O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (7.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9369 mL 9.6843 mL 19.3686 mL
5 mM 0.3874 mL 1.9369 mL 3.8737 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.4 mg/mL (0.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OglemilastGRC 3886GRC3886GRC-3886Phosphodiesterase (PDE)OrallypulmonarycellinfiltrationeosinophilianeutrophiliainflammatoryairwaydiseasesInhibitorinhibitorinhibit

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Product Name:
Oglemilast
Cat. No.:
HY-15178
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