2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Eggmanone

Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade.

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Eggmanone

Eggmanone Chemical Structure

CAS No. : 505068-32-6

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Based on 1 publication(s) in Google Scholar

Eggmanone Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade[1].

Molecular Weight

416.58

Formula

C20H20N2O2S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(SCC(C2=CC=CS2)=O)=NC3=C1C4=C(CCCC4)S3)CC(C)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (24.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4005 mL 12.0025 mL 24.0050 mL
5 mM 0.4801 mL 2.4005 mL 4.8010 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.31%

SDS (251 KB)

COA (254 KB) RP-HPLC (124 KB) MS (352 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4005 mL 12.0025 mL 24.0050 mL 60.0125 mL
5 mM 0.4801 mL 2.4005 mL 4.8010 mL 12.0025 mL
10 mM 0.2400 mL 1.2002 mL 2.4005 mL 6.0012 mL
15 mM 0.1600 mL 0.8002 mL 1.6003 mL 4.0008 mL
20 mM 0.1200 mL 0.6001 mL 1.2002 mL 3.0006 mL
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Eggmanone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eggmanone505068-32-6EGM1EGM 1EGM-1Phosphodiesterase (PDE)selectivePDE4HedgehogHhPDE4D3protein kinase AmalignanciesInhibitorinhibitorinhibit

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