505068-32-6
Chemical Structure
Eggmanone
Synonym(s): EGM1
- CAS No.: 505068-32-6
- Formula:C20H20N2O2S3
- Molecular Weight:416.58
IUPAC Name: 3-(2-methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
InChIKey: XAKJIQPEGSCYIP-UHFFFAOYSA-N
SMILES: O=C1N(C(SCC(C2=CC=CS2)=O)=NC3=C1C4=C(CCCC4)S3)CC(C)=C
Biological Activity: Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Eggmanone | 95.31% | Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade. | ||||||||||||||||||||
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Keywords
