2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. (S)-Gebr32a

(S)-Gebr32a is a potent PDE4 inhibitor with IC50 values of 19.5, 2.1 µM for PDE4 cat; PDE4D3, respectively.

For research use only. We do not sell to patients.

(S)-Gebr32a

(S)-Gebr32a Chemical Structure

CAS No. : 3055162-32-5

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Oil
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

(S)-Gebr32a Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

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Description

(S)-Gebr32a is a potent PDE4 inhibitor with IC50 values of 19.5, 2.1 µM for PDE4 cat; PDE4D3, respectively[1].

Molecular Weight

437.48

Formula

C22H29F2N3O4
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

FC(F)OC1=CC=C(C2=NN(C[C@@H](O)CN3CCOCC3)C=C2)C=C1OC4CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (285.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2858 mL 11.4291 mL 22.8582 mL
5 mM 0.4572 mL 2.2858 mL 4.5716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2858 mL 11.4291 mL 22.8582 mL 57.1455 mL
5 mM 0.4572 mL 2.2858 mL 4.5716 mL 11.4291 mL
10 mM 0.2286 mL 1.1429 mL 2.2858 mL 5.7145 mL
15 mM 0.1524 mL 0.7619 mL 1.5239 mL 3.8097 mL
20 mM 0.1143 mL 0.5715 mL 1.1429 mL 2.8573 mL
25 mM 0.0914 mL 0.4572 mL 0.9143 mL 2.2858 mL
30 mM 0.0762 mL 0.3810 mL 0.7619 mL 1.9048 mL
40 mM 0.0571 mL 0.2857 mL 0.5715 mL 1.4286 mL
50 mM 0.0457 mL 0.2286 mL 0.4572 mL 1.1429 mL
60 mM 0.0381 mL 0.1905 mL 0.3810 mL 0.9524 mL
80 mM 0.0286 mL 0.1429 mL 0.2857 mL 0.7143 mL
100 mM 0.0229 mL 0.1143 mL 0.2286 mL 0.5715 mL
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(S)-Gebr32a Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Gebr32a3055162-32-5Phosphodiesterase (PDE)PDE4 catInhibitorinhibitorinhibit

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