PDE4B - phosphodiesterase 4B Gene

Homo sapiens

Also known as DPDE4; PDEIVB

Gene ID: 5142 | Gene type: protein coding

About PDE4B

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:65,792,510-66,374,579 (from NCBI)

This gene has 18 transcripts (splice variants), 290 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues.

Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

PDE4B Products(7)

mRNA	Protein	Name
NM_001037339.2	NP_001032416.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
NM_001037340.3	NP_001032417.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3
NM_001037341.2	NP_001032418.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
NM_001297440.2	NP_001284369.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4
NM_001297441.1	NP_001284370.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5
NM_001297442.2	NP_001284371.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6
NM_002600.4	NP_002591.2	cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

PDE4B Protein Structure

PDEase_I

0
200
400
600
736 a.a.

Protein Preferred Names

Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

dunce-like phosphodiesterase E4

Recombinant PDE4B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74646	PDE4B Protein, Human (sf9, His-GST)	Q07343-2 (M1-T564)	≥95%

Related Diseases

Diseases

Alias

Ocular Hypotension

Hypotony Of Eye

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Brugada Syndrome 3

BRGDA3

Brugada Syndrome, Type 3

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities	Scn8
Sdsl	Shwachman-Diamond Syndrome-Like

Acrodysostosis

Acrodysplasia	Arkless-Graham Syndrome
Maroteaux-Malamut Syndrome	Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome
Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153192	Nerandomilast	Inhibitor	99.93%	Phase 3
HY-153192A	Nerandomilast dihydrate	Inhibitor	/	Phase 3
HY-16900	Rolipram	Inhibitor	99.58%	Phase 2
HY-10469	GSK256066	Inhibitor	98.15%	Phase 2
HY-117960	Orismilast	Inhibitor	99.37%	Phase 2
HY-112831	Osoresnontrine	Inhibitor	99.88%	Phase 2
HY-70069	GSK256066 Trifluoroacetate	Inhibitor	99.54%	Phase 2
HY-106003	GSK356278	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122942	Moracin M		98.90%	Unkown
HY-128358	MR-L2	Activator	99.23%	Unkown
HY-115687	PDE4B-IN-2	Inhibitor	99.21%	Unkown
HY-16900A	(R)-(-)-Rolipram	Inhibitor	99.89%	Unkown
HY-147830	PDE4B-IN-3	Inhibitor	99.40%	Unkown
HY-119190	PF-06445974	Inhibitor	98.23%	Unkown
HY-117977	FCPR03	Inhibitor	99.82%	Unkown
HY-103050	ML-030	Inhibitor	99.50%	Unkown
HY-100246	CI-1044	Inhibitor	98.03%	Unkown
HY-131707	LEO 39652	Inhibitor	99.51%	Unkown
HY-144683	PF-07038124	Inhibitor	/	Unkown
HY-115913	PDE4-IN-6	Inhibitor	/	Unkown
HY-121162	Mesembrine	Inhibitor	/	Unkown
HY-144684	PDE4-IN-8	Inhibitor	/	Unkown
HY-146201	PDE4B/7A-IN-1		/	Unkown
HY-146202	PDE4B/7A-IN-2		/	Unkown
HY-147950	PDE4-IN-10	Inhibitor	/	Unkown
HY-RS10223	PDE4B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDE4B	VGNC	VGNC:75916
Rattus norvegicus	PDE4B	RGD	RGD:3280
Bos taurus	PDE4B	VGNC	VGNC:32676
Felis catus	PDE4B	VGNC	VGNC:82496
Mus musculus	PDE4B	MGD	MGI:99557
Canis familiaris	PDE4B	VGNC	VGNC:44354

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