2. Metabolic Enzyme/Protease Anti-infection
  3. Phosphodiesterase (PDE) Bacterial
  4. PDE4B-IN-7

PDE4B-IN-7 is a PDE-4B inhibitor with an IC50 of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent.

For research use only. We do not sell to patients.

PDE4B-IN-7

PDE4B-IN-7 Chemical Structure

CAS No. : 1226697-79-5

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PDE4B-IN-7 Related Antibodies

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Description

PDE4B-IN-7 is a PDE-4B inhibitor with an IC50 of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent[1].

IC50 & Target[1]

PDE4B

160 nM (IC50)

In Vitro

PDE4B-IN-7 (Compound 17k) (1-1000 ng/mL; 20 min) potently inhibits human recombined PDE-4B in vitro with an IC50 of 160 nM[1].
PDE4B-IN-7 (31.15-500 μg/mL; 18-24 h) shows potent in vitro antibacterial activity against S. aureus (MIC = 0.07 μg/mL) and significant activity against E. coli (MIC = 8.074 μg/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE4B-IN-7 Related Antibodies

Cell Viability Assay[1]

Cell Line: S. aureus and E. coli
Concentration: 31.15–500 μg/mL
Incubation Time: 18-24 h
Result: Showed a MIC of 0.07 μg/mL for S. aureus and MIC of 8.074 μg/mL for E. coli.
In Vivo

PDE4B-IN-7 (Compound 17k) (2.5-10 mg/kg; i.p.) inhibits acetylcholine-induced bronchospasm in Hartley guinea pigs with an IC50 of 5.8 mg/kg i.p., achieving 78.3% inhibition at the 10 mg/kg dose[1].
PDE4B-IN-7 (i.p.) has an LD50 of 300 mg/kg via intraperitoneal injection in male albino mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hartley (male, 300-400 g, bronchospasm induced by acetylcholine injection)[1]
Dosage: 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration: i.p.
Result: Reduced acetylcholine-induced bronchospasm by 25.1% at 2.5 mg/kg.
Reduced acetylcholine-induced bronchospasm by 47.9% at 5 mg/kg.
Reduced acetylcholine-induced bronchospasm by 78.3% at 10 mg/kg.
Achieved an IC50 value of 5.8 mg/kg.
Molecular Weight

424.27

Formula

C15H14BrN5O3S
CAS No.
SMILES

O=C1C2=C(N=C(SCC(NC3=CC=C(Br)C=C3)=O)N2)N(C)C(N1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDE4B-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4B-IN-71226697-79-5Phosphodiesterase (PDE)BacterialS. aureusE. coliPDE-4Dmale albino miceHartley guinea pigsGram-positive bacterial strainsasthmaguinea pigsPDE-4BGram-negative bacterial strainsInhibitorinhibitorinhibit

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