2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Osoresnontrine

Osoresnontrine  (Synonyms: BI-409306)

Cat. No.: HY-112831 Purity: 99.46%
COA Handling Instructions

Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

For research use only. We do not sell to patients.

Osoresnontrine Chemical Structure

Osoresnontrine Chemical Structure

CAS No. : 1189767-28-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 102 In-stock
Solution
10 mM * 1 mL in DMSO USD 102 In-stock
Solid
5 mg USD 93 In-stock
10 mg USD 150 In-stock
25 mg USD 250 In-stock
50 mg USD 450 In-stock
100 mg USD 750 In-stock
200 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Osoresnontrine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Osoresnontrine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

IC50 & Target[1]

PDE9A

52 nM (IC50)

PDE1C

1 μM (IC50)

PDE1A

1.4 μM (IC50)

In Vitro

Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 µM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Osoresnontrine Related Antibodies
Clinical Trial
Molecular Weight

311.34

Appearance

Solid

Formula

C16H17N5O2
CAS No.
SMILES

O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 75 mg/mL (240.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2119 mL 16.0596 mL 32.1192 mL
5 mM 0.6424 mL 3.2119 mL 6.4238 mL
10 mM 0.3212 mL 1.6060 mL 3.2119 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (8.03 mM); Clear solution; Need warming

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Osoresnontrine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Osoresnontrine1189767-28-9BI-409306BI409306BI 409306Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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