1189767-28-9
Chemical Structure
Osoresnontrine
Synonym(s): BI-409306
- CAS No.: 1189767-28-9
- Formula:C16H17N5O2
- Molecular Weight:311.34
IUPAC Name: 6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
InChIKey: BZTIJCSHNVZMES-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1
Biological Activity: Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.
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Osoresnontrine | 99.94% | Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders. | ||||||||||||||||||||
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Keywords
