PF-4800567 hydrochloride
Based on 2 publication(s) in Google Scholar
PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC50?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways.
For research use only. We do not sell to patients.
- CAS No.: 1391052-28-0
- Formula: C17H19Cl2N5O2
- Molecular Weight:396.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
IC50: 32 nM ((CK1?)[1]
Chemical Information
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CAS No. 1391052-28-0
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Molecular Weight 396.27
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Formula C17H19Cl2N5O2
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SMILES
NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
EMBO J
2024 Oct;43(20):4752-4785. PMID: 39256562
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-4800567 hydrochloride Related Classifications
HY-12470A Related Classifications
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