1391052-28-0
1391052-28-0
Chemical Structure
PF-4800567 hydrochloride
- CAS No.: 1391052-28-0
- Formula:C17H19Cl2N5O2
- Molecular Weight:396.27
IUPAC Name: 3-((3-chlorophenoxy)methyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
InChIKey: QZXZQMUZEHTFHD-UHFFFAOYSA-N
SMILES: NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1.[H]Cl
Biological Activity: PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC50?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways[1].
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PF-4800567 hydrochloride | PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC50?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways. | |||||||||||||||||||||
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