(S)-C33
Based on 1 Customer Validation
(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research.
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 2066488-39-7
- Formula: C18H20ClN5O
- Molecular Weight:357.84
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
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Biological Activity
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PDE9A 11 nM (IC50) |
PDE5A1 366 nM (IC50) |
PDE1B 554 nM (IC50) |
PDE4D2 1.3 μM (IC50) |
PDE10A1 2.3 μM (IC50) |
PDE2A 2.4 μM (IC50) |
(S)-C33 shows the T1/2 values of 105 and 54 minutes in human and mouse microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2066488-39-7
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Appearance Solid
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Molecular Weight 357.84
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Formula C18H20ClN5O
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Color White to off-white
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SMILES
O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (279.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7945 mL | 13.9727 mL | 27.9455 mL | 69.8636 mL |
| 5 mM | 0.5589 mL | 2.7945 mL | 5.5891 mL | 13.9727 mL | |
| 10 mM | 0.2795 mL | 1.3973 mL | 2.7945 mL | 6.9864 mL | |
| 15 mM | 0.1863 mL | 0.9315 mL | 1.8630 mL | 4.6576 mL | |
| 20 mM | 0.1397 mL | 0.6986 mL | 1.3973 mL | 3.4932 mL | |
| 25 mM | 0.1118 mL | 0.5589 mL | 1.1178 mL | 2.7945 mL | |
| 30 mM | 0.0932 mL | 0.4658 mL | 0.9315 mL | 2.3288 mL | |
| 40 mM | 0.0699 mL | 0.3493 mL | 0.6986 mL | 1.7466 mL | |
| 50 mM | 0.0559 mL | 0.2795 mL | 0.5589 mL | 1.3973 mL | |
| 60 mM | 0.0466 mL | 0.2329 mL | 0.4658 mL | 1.1644 mL | |
| 80 mM | 0.0349 mL | 0.1747 mL | 0.3493 mL | 0.8733 mL | |
| 100 mM | 0.0279 mL | 0.1397 mL | 0.2795 mL | 0.6986 mL |
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