1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. (S)-C33

(S)-C33 

Cat. No.: HY-124775
Handling Instructions

(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research.

For research use only. We do not sell to patients.

(S)-C33 Chemical Structure

(S)-C33 Chemical Structure

CAS No. : 2066488-39-7

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Description

(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research[1].

IC50 & Target

PDE9A

11 ± 4 nM (IC50)

PDE5A1

366 ± 38 nM (IC50)

PDE1B

554 ± 64 nM (IC50)

PDE4D2

1.3 ± 0.1 μM (IC50)

PDE10A1

2.3 ± 0.3 μM (IC50)

PDE2A

2.4 ± 0.5 μM (IC50)

Molecular Weight

357.84

Formula

C18H20ClN5O

CAS No.
SMILES

O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[[email protected]](C4=CC=C(Cl)C=C4)C)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (279.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7945 mL 13.9727 mL 27.9454 mL
5 mM 0.5589 mL 2.7945 mL 5.5891 mL
10 mM 0.2795 mL 1.3973 mL 2.7945 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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(S)-C33
Cat. No.:
HY-124775
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