(R)-Irsenontrine
Based on 1 Customer Validation
(R)-Irsenontrine ((R)-E2027), the R-enantiomer of Irsenontrine (HY-132821), is a potent phosphodiesterase 9 (PDE9) inhibitor with an IC50 value of 0.041 μM. (R)-Irsenontrine can be used for the research of neurological diseases.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 1429509-81-8
- Formula: C22H22N4O3
- Molecular Weight:390.44
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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PDE9 0.041 μM (IC50) |
Chemical Information
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CAS No. 1429509-81-8
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Appearance Solid
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Molecular Weight 390.44
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Formula C22H22N4O3
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Color White to off-white
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SMILES
O=C1C2=C(N([C@]3([H])CCOC3)N=C2)C4=CC=C(C5=C(C)C=NC(OC)=C5C)C=C4N1
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Synonyms
(R)-E2027
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 25 mg/mL (64.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5612 mL | 12.8061 mL | 25.6121 mL | 64.0303 mL |
| 5 mM | 0.5122 mL | 2.5612 mL | 5.1224 mL | 12.8061 mL | |
| 10 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4030 mL | |
| 15 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL | |
| 20 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2015 mL | |
| 25 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 30 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1343 mL | |
| 40 mM | 0.0640 mL | 0.3202 mL | 0.6403 mL | 1.6008 mL | |
| 50 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL | |
| 60 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL |
(R)-Irsenontrine Related Classifications
HY-132821B Related Classifications
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