PF-06445974 precursor

Cat. No.: HY-206852 Purity: 99.67%: Data Sheet
COA

SDS
Handling Instructions
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PF-06445974 precursor (Compound 28) is a nitro precursor and synthetic intermediate. PF-06445974 precursor can be used for the synthesis of PF-06445974 (HY-119190). PF-06445974 is a positron emission tomography (PET) compound that acts potently on PDE4B.

For research use only. We do not sell to patients.

PF-06445974 precursor Chemical Structure

CAS No. : 2055777-51-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

PDE4B

Molecular Weight

373.36

Formula

C₂₀H₁₅N₅O₃

CAS No.

2055777-51-8

Appearance

Solid

Color

Yellow to green

SMILES

N#CC1=C([N+]([O-])=O)C=C(C2=C(C(N(C3CC3)CC4)=O)N4C5=C2N=CC=C5)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (133.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6784 mL	13.3919 mL	26.7838 mL
5 mM	0.5357 mL	2.6784 mL	5.3568 mL
10 mM	0.2678 mL	1.3392 mL	2.6784 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.67%

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Data Sheet (278 KB) SDS (252 KB)

COA (259 KB) HNMR (229 KB) RP-HPLC (254 KB) MS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang L, et al. The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging. J Med Chem. 2017;60(20):8538-8551. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6784 mL	13.3919 mL	26.7838 mL	66.9595 mL
	5 mM	0.5357 mL	2.6784 mL	5.3568 mL	13.3919 mL
	10 mM	0.2678 mL	1.3392 mL	2.6784 mL	6.6960 mL
	15 mM	0.1786 mL	0.8928 mL	1.7856 mL	4.4640 mL
	20 mM	0.1339 mL	0.6696 mL	1.3392 mL	3.3480 mL
	25 mM	0.1071 mL	0.5357 mL	1.0714 mL	2.6784 mL
	30 mM	0.0893 mL	0.4464 mL	0.8928 mL	2.2320 mL
	40 mM	0.0670 mL	0.3348 mL	0.6696 mL	1.6740 mL
	50 mM	0.0536 mL	0.2678 mL	0.5357 mL	1.3392 mL
	60 mM	0.0446 mL	0.2232 mL	0.4464 mL	1.1160 mL
	80 mM	0.0335 mL	0.1674 mL	0.3348 mL	0.8370 mL
	100 mM	0.0268 mL	0.1339 mL	0.2678 mL	0.6696 mL