1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. 5-HT Receptor
    Phosphodiesterase (PDE)
  3. Mesembrine

Mesembrine (Synonyms: (+)-Mesembrine)

Cat. No.: HY-121162
Handling Instructions

Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM.

For research use only. We do not sell to patients.

Mesembrine Chemical Structure

Mesembrine Chemical Structure

CAS No. : 468-53-1

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Description

Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM[1][2].

IC50 & Target[1]

PDE4B

7.8 μM (IC50)

serotonin

1.4 nM (Ki)

In Vitro

Mesembrine can bind to cloned human cannabinoid CB1 receptors in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

289.37

Formula

C₁₇H₂₃NO₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Mesembrine
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