(-)-Mesembrine
Based on 1 Customer Validation
(-)-Mesembrine is a serotonin transporter (SERT) inhibitor. (-)-Mesembrine inhibits serotonin reuptake. (-)-Mesembrine exerts anxiolytic, mood-enhancing and anti-addictive effects. (-)-Mesembrine is applicable to research on mild-to-moderate depression, anxiety disorders and stress-related conditions.
For research use only. We do not sell to patients.
- Purity: 96.15%
- CAS No.: 24880-43-1
- Formula: C17H23NO3
- Molecular Weight:289.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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Microbial Metabolite |
(−)-Mesembrine potently binds to the serotonin transporter protein[1].
(−)-Mesembrine weakly inhibits phosphodiesterase type 4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 24880-43-1
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Appearance Solid
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Molecular Weight 289.37
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Formula C17H23NO3
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Color White to off-white
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SMILES
O=C1CC[C@@]2(C3=CC=C(OC)C(OC)=C3)CCN(C)[C@@]2([H])C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : 10 mg/mL (34.56 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 3.4558 mL | 17.2789 mL | 34.5578 mL | 86.3946 mL |
| 5 mM | 0.6912 mL | 3.4558 mL | 6.9116 mL | 17.2789 mL | |
| 10 mM | 0.3456 mL | 1.7279 mL | 3.4558 mL | 8.6395 mL | |
| 15 mM | 0.2304 mL | 1.1519 mL | 2.3039 mL | 5.7596 mL | |
| 20 mM | 0.1728 mL | 0.8639 mL | 1.7279 mL | 4.3197 mL | |
| 25 mM | 0.1382 mL | 0.6912 mL | 1.3823 mL | 3.4558 mL | |
| 30 mM | 0.1152 mL | 0.5760 mL | 1.1519 mL | 2.8798 mL |