468-53-1
468-53-1
Chemical Structure
Mesembrine
Synonym(s): (+)-Mesembrine
- CAS No.: 468-53-1
- Formula:C17H23NO3
- Molecular Weight:289.37
IUPAC Name: (3aR,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-6H-indol-6-one
InChIKey: DAHIQPJTGIHDGO-IAGOWNOFSA-N
SMILES: O=C1CC[C@]2(C3=CC=C(OC)C(OC)=C3)CCN(C)[C@]2([H])C1
Biological Activity: Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM[1][2].
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Mesembrine | Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM. | |||||||||||||||||||||
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References
- [1]. John L Krstenansky. Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. J Ethnopharmacol. 2017 Jan 4;195:10-19. [Content Brief]
- [2]. Golo M J Meyer, et al. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem. 2015 Jan;407(3):761-78. [Content Brief]
Keywords
