PDE4B-IN-6
PDE4B-IN-6 (compound 4i) is a potent and selective PDE4B inhibitor with an IC50 of 7.42 nM. PDE4B-IN-6 shows ~195- and ~169-fold selectivity for PDE4B over PDE4A (IC50 = 1540 nM) and PDE4C (IC50 = 1260 nM), respectively. PDE4B-IN-6 increases cAMP level and suppresses TNF-α expression. PDE4B-IN-6 shows favorable antioxidant profiles and low cytotoxicity. PDE4B-IN-6 can be used for chronic obstructive pulmonary disease (COPD) research.
For research use only. We do not sell to patients.
- Formula: C22H24F2N2O7
- Molecular Weight:466.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PDE4B 7.42 nM (IC50) |
PDE4A 1540 nM (IC50) |
PDE4C 1260 nM (IC50) |
Chemical Information
-
Molecular Weight 466.43
-
Formula C22H24F2N2O7
-
SMILES
O=C(NNC(C1=CC=C(OC(F)F)C(OCC2CC2)=C1)=O)C3=CC(OC)=C(OC)C(OC)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE4B-IN-6 Related Classifications
HY-179504 Related Classifications
Powered by Bioz