PDE4B-IN-6
PDE4B-IN-6 (compound 4i) is a potent and selective PDE4B inhibitor with an IC50 of 7.42 nM. PDE4B-IN-6 shows ~195- and ~169-fold selectivity for PDE4B over PDE4A (IC50 = 1540 nM) and PDE4C (IC50 = 1260 nM), respectively. PDE4B-IN-6 increases cAMP level and suppresses TNF-α expression. PDE4B-IN-6 shows favorable antioxidant profiles and low cytotoxicity. PDE4B-IN-6 can be used for chronic obstructive pulmonary disease (COPD) research.
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- 화학식: C22H24F2N2O7
- 분자량:466.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PDE4B 7.42 nM (IC50) |
PDE4A 1540 nM (IC50) |
PDE4C 1260 nM (IC50) |
Chemical Information
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분자량 466.43
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화학식 C22H24F2N2O7
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SMILES
O=C(NNC(C1=CC=C(OC(F)F)C(OCC2CC2)=C1)=O)C3=CC(OC)=C(OC)C(OC)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE4B-IN-6 Related Classifications
HY-179504 Related Classifications
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