2. Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Phosphodiesterase (PDE) Interleukin Related TNF Receptor IFNAR
  4. AN-2898

AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research.

For research use only. We do not sell to patients.

AN-2898

AN-2898 Chemical Structure

CAS No. : 906673-33-4

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AN-2898 Related Antibodies

Top Publications Citing Use of Products

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View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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  • Customer Review

Description

AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research[1].

IC50 & Target[1]

PDE1A

1.7 μM (IC50)

PDE2A

9.8 μM (IC50)

PDE3A

4.12 μM (IC50)

PDE4

0.027 μM (IC50)

PDE7A

0.21 μM (IC50)

PDE4B1

0.24 μM (IC50)

PDE4A1

0.35 μM (IC50)

PDE4D2

0.84 μM (IC50)

IL-2

 

IL-10

 

IL-5

 

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
0.24 μM
Compound: 19
Inhibition of human PDE4B1 expressed in baculovirus infected sf9 cells incubated for 30 mins
Inhibition of human PDE4B1 expressed in baculovirus infected sf9 cells incubated for 30 mins
[PMID: 26908025]
Clinical Trial
Molecular Weight

276.05

Formula

C15H9BN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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AN-2898 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN-2898906673-33-4AN2898AN 2898Phosphodiesterase (PDE)Interleukin RelatedTNF ReceptorIFNARILTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorPDE4PDE4B1PDE4A1APDE4D2Sf9 cellsAtopic dermatitisADPsoriasisinhibitorinhibit

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