NVP-ABE171
NVP-ABE171 is an efficient, long-lasting and orally active PDE4 inhibitor with IC50 values for PDE4D, PDE4B, PDE4A and PDE4C of 1.5, 34, 602 and 1230 nM respectively. NVP-ABE171 enhances the cAMP accumulation induced by isoproterenol, inhibits the oxidative burst of eosinophils and the release of inflammatory cytokines from T cells and monocytes. NVP-ABE171 exhibits potent anti-inflammatory activity in animal models of asthma and pulmonary inflammation. NVP-ABE171 can be used for research on asthma and chronic obstructive pulmonary disease.
For research use only. We do not sell to patients.
- CAS No.: 426268-06-6
- Formula: C21H12N4O3
- Molecular Weight:368.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PDE4D 1.5 nM (IC50) |
PDE4B 34 nM (IC50) |
PDE4A 602 nM (IC50) |
PDE4C 1230 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Eosinophil | ED50 |
0.3 μM/g
Compound: NVP-ABE171
|
Anti-inflammatory activity against ovalbumin induced lung inflammatory rat model assessed as reduction in eosinophil influx
Anti-inflammatory activity against ovalbumin induced lung inflammatory rat model assessed as reduction in eosinophil influx
|
[PMID: 33569941] |
| Neutrophil | ED50 |
7.6 μM/g
Compound: NVP-ABE171
|
Anti-inflammatory activity in LPS-induced inflammatory mouse model assessed as reduction in neutrophil influx
Anti-inflammatory activity in LPS-induced inflammatory mouse model assessed as reduction in neutrophil influx
|
[PMID: 33569941] |
| PBMC | EC50 |
67.6 nM
Compound: NVP-ABE171
|
Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis
Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis
|
[PMID: 33569941] |
| PBMC | IC50 |
68 nM
Compound: 1
|
Inhibition of TNF-alpha release from human peripheral blood mononuclear cells
Inhibition of TNF-alpha release from human peripheral blood mononuclear cells
|
[PMID: 11755362] |
Chemical Information
-
CAS No. 426268-06-6
-
Molecular Weight 368.34
-
Formula C21H12N4O3
-
SMILES
O=C(O)C1=CC=C(C2=NC(C3=CC4=NON=C4C=C3)=C5N=CC=CC5=C2)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Trifilieff A, et al. Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities. J Pharmacol Exp Ther. 2002 Apr;301(1):241-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz