PDE4-IN-10
PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro.
For research use only. We do not sell to patients.
- CAS No.: 2413564-66-4
- Formula: C18H13N
- Molecular Weight:243.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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PDE4B 7.01 ± 1.0 μM (IC50) |
PDE4D |
In Vitro
PDE4-IN-10 (compound 7a) shows 64.56% inhibition at 10 µM against PDE4B, 54% inhibition at 30 µM but 17% inhibition at 10 µM against PDE4D, indicating its selectivity (~3.8 fold) towards PDE4B over PDE4D[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2413564-66-4
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Molecular Weight 243.30
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Formula C18H13N
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SMILES
CC1=CC2=C3C=CC=CC3=CN=C2C4=CC=CC=C14
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE4-IN-10 Related Classifications
HY-147950 Related Classifications
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