LT-104A

Cat. No.: HY-179407: Data Sheet Handling Instructions
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LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC₅₀ = 1.9 μM) and inhibits PDE4D3 activity (IC₅₀ = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research.

For research use only. We do not sell to patients.

LT-104A Chemical Structure

CAS No. : 2574572-03-3

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Biological Activity
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References
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Description

IC₅₀ & Target

PDE4D3

9.3 μM (IC₅₀)

In Vitro

LT-104A (1-30 μM; 24 h) reduces LPS (HY-D1056) -induced Il1b and Nos2 mRNA expression in J774A.1 macrophages^[1].
LT-104A (1-30 μM; 24 h) decreases LPS -induced nitric oxide production in J774A.1 macrophages^[1].
LT-104A (0.1-30μM; 30 min) increases intracellular cAMP levels in HEK293 cells in a concentration-dependent manner (EC₅₀ = 1.9 μM)^[1].
LT-104A (0.1-30 μM; 6 h) enhances CRE-luciferase activity through activation of the cAMP-PKA-CREB signaling pathway in HEK293 cells^[1].
LT-104A (0.1-100 μM) inhibits recombinant PDE4D3 enzymatic activity with an IC₅₀ of 9.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	LPS(1 μg/mL, 24 h)induced J774A.1 macrophages
Concentration:	1 , 3 , 10 , 30 μM
Incubation Time:	30 min before LPS treatment for 24 h.
Result:	Reduced LPS-induced Il1b and Nos2 mRNA expression.

Molecular Weight

542.62

Formula

C₃₃H₃₄O₇

CAS No.

2574572-03-3

SMILES

O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Coffey C, et al. Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans. Eur J Med Chem. 2026;302(Pt 1):118285. doi:10.1016/j.ejmech.2025.118285 [Content Brief]

LT-104A Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LT-104A2574572-03-3Phosphodiesterase (PDE)PDE4 inhibitorPDE4D3J774A.1 macrophagesHEK293 cellsLPS-induced inflammationInhibitorinhibitorinhibit

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