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Cat. No.: HY-179407

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LT-104A

LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC₅₀ = 1.9 μM) and inhibits PDE4D3 activity (IC₅₀ = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research.

For research use only. We do not sell to patients.

CAS No.: 2574572-03-3
Formula: C₃₃H₃₄O₇
Molecular Weight:542.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

LT-104A Chemical Structure

CAS No.: 2574572-03-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

PDE4D3

9.3 μM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

LT-104A (1-30 μM; 24 h) reduces LPS (HY-D1056) -induced Il1b and Nos2 mRNA expression in J774A.1 macrophages^[1].
LT-104A (1-30 μM; 24 h) decreases LPS -induced nitric oxide production in J774A.1 macrophages^[1].
LT-104A (0.1-30μM; 30 min) increases intracellular cAMP levels in HEK293 cells in a concentration-dependent manner (EC₅₀ = 1.9 μM)^[1].
LT-104A (0.1-30 μM; 6 h) enhances CRE-luciferase activity through activation of the cAMP-PKA-CREB signaling pathway in HEK293 cells^[1].
LT-104A (0.1-100 μM) inhibits recombinant PDE4D3 enzymatic activity with an IC₅₀ of 9.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

LPS(1 μg/mL, 24 h)induced J774A.1 macrophages
Concentration:

1 , 3 , 10 , 30 μM
Incubation Time:

30 min before LPS treatment for 24 h.
Result:

Reduced LPS-induced Il1b and Nos2 mRNA expression.

Chemical Information

CAS No. 2574572-03-3
Molecular Weight 542.62
Formula C₃₃H₃₄O₇
SMILES

O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Coffey C, et al. Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans. Eur J Med Chem. 2026;302(Pt 1):118285. doi:10.1016/j.ejmech.2025.118285 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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