2574572-03-3
2574572-03-3
Chemical Structure
LT-104A
- CAS No.: 2574572-03-3
- Formula:C33H34O7
- Molecular Weight:542.62
InChIKey: GYBKOVODFIQHQT-HCWRMBROSA-N
SMILES: O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5
Biological Activity: LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research[1].
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LT-104A | LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research. | |||||||||||||||||||||
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References
Keywords
