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Cat. No.: HY-120945

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PDE10A-IN-1

PDE10A-IN-1 is a phosphodiesterase 10A (PDE10A) inhibitor with an IC₅₀ of 250 nM and the ability to cross the blood-brain barrier. PDE10A-IN-1 can be used in research on neurological disorders such as schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 1354404-30-0
Formula: C₂₃H₁₉N₃O₂
Molecular Weight:369.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PDE10A-IN-1 Chemical Structure

CAS No.: 1354404-30-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

PDE10A

250 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE10A-IN-1 (Compound 8) (2 µM) inhibits PDE10A enzyme (IC₅₀ = 250 nM)^[1].
PDE10A-IN-1 exhibits metabolic stability in human liver microsomes with an HLM Cl_int of 1.1 L/min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

PDE10A-IN-1 exhibits in vivo antipsychotic activity in Rats (Schizophrenia model) (with a ED₅₀ of 60 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1354404-30-0
Molecular Weight 369.42
Formula C₂₃H₁₉N₃O₂
SMILES

O=C(C=1C=CN=CC1)N(C2=CC=C(OCC3=NC=4C=CC=CC4C=C3)C=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kilburn JP, et al. N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem. 2013;21(19):6053-6062. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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