PYCR3 - pyrroline-5-carboxylate reductase 3 Gene

Also Known as PYCRL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65263

Summary

This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of Enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]
Ubiquitous expression in kidney (RPKM 2.8), thyroid (RPKM 2.6) and 25 other tissues.

PYCR3 Products (1)

mRNA Protein Name
NG_051357.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables pyrroline-5-carboxylate reductase activity IDA
IDA: Inferred from direct assay
23024808 GOA
Biological Process GO Annotation Evidence References Source
involved in L-proline biosynthetic process IDA
IDA: Inferred from direct assay
23024808 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23024808 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYCR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PYCR3 Q53H96 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
PYCR3 Q53H96 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
PYCR3 Q53H96 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
PYCR3 Q53H96 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction