2. Gene
  3. SH3RF2 - SH3 domain containing ring finger 2 Gene

SH3RF2 - SH3 domain containing ring finger 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEPP1; POSHER; RNF158; PPP1R39

Gene ID: 153769 | Gene type: protein coding

About SH3RF2

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:145,936,578-146,081,773 (from NCBI)

This gene has 7 transcripts (splice variants), 163 orthologues and 12 paralogues. Biased expression in skin (RPKM 22.7), testis (RPKM 19.4) and 12 other tissues.

Summary

Enables protein Phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of cellular protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SH3RF2 Products(1)

mRNA Protein Name
NM_152550.4 NP_689763.4 E3 ubiquitin-protein ligase SH3RF2

SH3RF2 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 52)

SH3_2

SH3_2: Variant SH3 domain (129 - 182)

SH3_9

SH3_9: Variant SH3 domain (194 - 248)

SH3_9

SH3_9: Variant SH3 domain (387 - 436)

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  • 729 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF2

POSH-eliminating RING protein

Related Diseases

Diseases Alias
Ureter Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Ureter

Ureteral Urothelial Cell Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12845 SH3RF2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SH3RF2 MGD MGI:2444628
Macaca mulatta SH3RF2 VGNC VGNC:77315
Canis familiaris SH3RF2 VGNC VGNC:46133
Felis catus SH3RF2 VGNC VGNC:65114
Rattus norvegicus SH3RF2 RGD RGD:1308415
Bos taurus SH3RF2 VGNC VGNC:34580