SH3RF2 - SH3 domain containing ring finger 2 Gene

Also Known as HEPP1; POSHER; RNF158; PPP1R39

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 153769

About SH3RF2

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:145,936,578-146,081,773 (from NCBI)

This gene has 7 transcripts (splice variants), 163 orthologues and 12 paralogues. Biased expression in skin (RPKM 22.7), testis (RPKM 19.4) and 12 other tissues.

Summary

Enables protein Phosphatase 1 binding activity and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of cellular protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SH3RF2 Products (1)

mRNA Protein Name
NM_152550.4 NP_689763.4 E3 ubiquitin-protein ligase SH3RF2

SH3RF2 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 52)

SH3_2

SH3_2: Variant SH3 domain (129 - 182)

SH3_9

SH3_9: Variant SH3 domain (194 - 248)

SH3_9

SH3_9: Variant SH3 domain (387 - 436)

  • 0
  • 200
  • 400
  • 600
  • 729 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF2

  • POSH-eliminating RING protein

SH3RF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SH3RF2 Q8TEC5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
31515488
Intra
SH3RF2 Q8TEC5 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 EFS Homo sapiens O43281-2
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 EFS Homo sapiens O43281-2
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
SH3RF2 Q8TEC5 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 PPP1CA Homo sapiens P62136
Pull Down
19389623
Intra
SH3RF2 Q8TEC5 PPP1CA Homo sapiens P62136
Y2H
22321011
Intra
SH3RF2 Q8TEC5 PPP1CA Homo sapiens P62136
Far-WB
19389623
Intra
SH3RF2 Q8TEC5 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
SH3RF2 Q8TEC5 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
SH3RF2 Q8TEC5 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
SH3RF2 Q8TEC5 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ureter Transitional Cell Carcinoma

  • Transitional Cell Carcinoma Of Ureter

  • Ureteral Urothelial Cell Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12845 SH3RF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SH3RF2 MGD MGI:2444628
Macaca mulatta SH3RF2 VGNC VGNC:77315
Canis familiaris SH3RF2 VGNC VGNC:46133
Felis catus SH3RF2 VGNC VGNC:65114
Rattus norvegicus SH3RF2 RGD RGD:1308415
Bos taurus SH3RF2 VGNC VGNC:34580
Others SH3RF2 NCBI