FOXR2 - forkhead box R2 Gene

Also Known as FOXN6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 139628

About FOXR2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,623,400-55,626,192 (from NCBI)

This gene has 1 transcript (splice variant), 131 orthologues and 42 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FOXR2 Products (1)

mRNA	Protein	Name
NM_198451.4	NP_940853.1	forkhead box protein R2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXR2 Protein Structure

Forkhead

0
100
200
311 a.a.

Protein Preferred Names	Protein Names
forkhead box protein R2	forkhead box protein N6

FOXR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	25416956
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	25416956
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cns Neuroblastoma With Foxr2 Activation	Central Nervous System Neuroblastoma With Foxr2 Activation Cns Nb-Foxr2 Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor	Central Nervous System Germ Cell Tumour Germ Cell Tumor Of The Cns Germ Cell Tumour Of The Cns
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Pineal Parenchymal Tumor Of Intermediate Differentiation	Pineal Parenchymal Tumour Of Intermediate Differentiation Pineal Parenchymal Tumors Of Intermediate Differentiation Pptid
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Astroblastoma	Cerebral Astroblastoma
Medulloepithelioma	Diktyoma, Malignant Medulloepithelioma, Central Nervous System Medulloepithelioma Of The Central Nervous System
Embryonal Tumor With Multilayered Rosettes, C19mc-Altered	Ependymoblastoma
Central Nervous System Primitive Neuroectodermal Neoplasm	Cpnet
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS05079	FOXR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21575	Foxr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28093	Foxr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXR2	VGNC	VGNC:40970
Mus musculus	FOXR2	MGD	MGI:3511682
Bos taurus	FOXR2	VGNC	VGNC:29105
Rattus norvegicus	FOXR2	RGD	RGD:1564437
Others	FOXR2	NCBI