SEC24A - SEC24 homolog A, COPII coat complex component Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10802

About SEC24A

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,648,382-134,727,909 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in small intestine (RPKM 10.1), duodenum (RPKM 10.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SEC24A Products (2)

mRNA Protein Name
NM_001252231.2 NP_001239160.1 protein transport protein Sec24A isoform 2
NM_021982.3 NP_068817.1 protein transport protein Sec24A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17499046 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
18843296 GOA
Biological Process GO Annotation Evidence References Source
involved in COPII-coated vesicle cargo loading IDA
IDA: Inferred from direct assay
17499046 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
20427317 GOA
Cellular Component GO Annotation Evidence References Source
part of COPII vesicle coat IDA
IDA: Inferred from direct assay
17499046 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC24A Protein Structure

zf-Sec23_Sec24

zf-Sec23_Sec24: Sec23/Sec24 zinc finger (428 - 465)

Sec23_trunk

Sec23_trunk: Sec23/Sec24 trunk domain (501 - 739)

Sec23_BS

Sec23_BS: Sec23/Sec24 beta-sandwich domain (744 - 828)

Sec23_helical

Sec23_helical: Sec23/Sec24 helical domain (841 - 940)

Gelsolin

Gelsolin: Gelsolin repeat (966 - 1038)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1093 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec24A

  • SEC24 family, member A

SEC24A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEC24A O95486 TFG Homo sapiens Q92734
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ceroid Lipofuscinosis, Neuronal, 8

  • Neuronal Ceroid Lipofuscinosis 8

  • CLN8

  • Cln8 Disease

  • Epilepsy Mental Deterioration Finnish Type

  • Northern Epilepsy

  • Cln8 Disease, Epmr

  • Cln8 Disease, Northern Epilepsy Variant

  • Cln8 Disease, Late Infantile

  • Ceroid Lipofuscinosis Neuronal 8

  • Ncl, Northern Epilepsy Variant

  • Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

  • Progressive Epilepsy - Intellectual Disability, Finnish Type

  • Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type

  • Turkish Variant Late Infantile Ncl

  • Ceroid Lipofuscinosis, Neuronal 8

  • Lipofuscinosis, Ceroid, Neuronal, Type 8

  • Northern Epilepsy Syndrome
Craniolenticulosutural Dysplasia

  • Boyadjiev-Jabs Syndrome

  • CLSD

  • Cranio-Lenticulo-Sutural Dysplasia

  • Cranio-Lenticulo-Sutural Dysplasia, Clsd
Anemia, Congenital Dyserythropoietic, Type Ii

  • Congenital Dyserythropoietic Anemia Type Ii

  • CDAN2

  • Cda Ii

  • Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test

  • Cda Type Ii

  • Congenital Dyserythropoietic Anemia Type 2

  • Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test

  • Sec23b-Cdg

  • Congenital Dyserythropoietic Anemia, Type Ii

  • Dyserythropoietic Anemia, Hempas Type

  • Hempas

  • Cda Type 2

  • Dyserythropoietic Anemia, Congenital, Type Ii

  • Cda, Type Ii

  • Congenital Dyserythropoietic Anaemia Type 2

  • Congenital Dyserythropoietic Anaemia Type Ii

  • Anemia, Dyserythropoietic, Congenital Type 2

  • Hempas Anemia

  • Dyserythropoietic Anemia, Congenital Type 2

  • Anemia, Congenital Dyserythropoietic, 2

  • Dyserythropoietic Anemia Hempas Type

  • Anemia, Dyserythropoietic Congenital, Type Ii

  • Anemia, Dyserythropoietic, Congenital, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12615 SEC24A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SEC24A MGD MGI:1924621
Bos taurus SEC24A VGNC VGNC:34413
Rattus norvegicus SEC24A RGD RGD:1309451
Felis catus SEC24A VGNC VGNC:64967
Macaca mulatta SEC24A VGNC VGNC:77152
Canis familiaris SEC24A VGNC VGNC:45972
Others SEC24A NCBI