POC5 - POC5 centriolar protein Gene

Also Known as C5orf37

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 134359

About POC5

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:75,674,124-75,717,437 (from NCBI)

This gene has 14 transcripts (splice variants) and 94 orthologues. Broad expression in testis (RPKM 10.4), lymph node (RPKM 4.7) and 24 other tissues.

Summary

Predicted to enable identical protein binding activity. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

POC5 Products (2)

mRNA	Protein	Name
NM_001099271.2	NP_001092741.1	centrosomal protein POC5 isoform 1
NM_152408.3	NP_689621.2	centrosomal protein POC5 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
centrosomal protein POC5	POC5 centriolar protein homolog

POC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Y2H Prey Pooling	25416956
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Y2H Array	25416956
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	BioID	26638075
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Anti Tag CoIP	33961781
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Anti Bait CoIP	35709258
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Validated Y2H	25416956
Intra	POC5	Q8NA72	CETN1	Homo sapiens	Q12798	Y2H Array	31515488
Intra	POC5	Q8NA72	TUBA4A	Homo sapiens	P68366	Anti Tag CoIP	30845169
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Y2H Prey Pooling	25416956
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	BioID	26638075
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Validated Y2H	25416956
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Anti Bait CoIP	35709258
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Y2H Array	25416956
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Anti Tag CoIP	33961781
Intra	POC5	Q8NA72	FAM161A	Homo sapiens	Q3B820	BioID	26638075
Intra	POC5	Q8NA72	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	POC5	Q8NA72	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

POC5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86279	POC5 Antibody (YA5971)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Syndromic Rod-Cone Dystrophy	Syndromic Retinitis Pigmentosa
Idiopathic Scoliosis	Scoliosis Idiopathic
Scoliosis
Orofaciodigital Syndrome I	OFD1 Orofaciodigital Syndrome 1 Oral-Facial-Digital Syndrome, Type I Oral-Facial-Digital Syndrome 1 Ofds I Papillon-Leage And Psaume Syndrome Papillon-Leage-Psaume Syndrome Oral-Facial-Digital Syndrome Type 1 Orofaciodigital Syndrome Type 1 Orofaciodigital Syndromes Orofaciodigital Syndrome Type I Oral-Facial-Digital Syndrome Type I Ofd Syndrome 1 Ofds 1 Oral Facial Digital Syndrome 1 Oral Facial Digital Syndrome Type 1 Papillon-League-Psaume Syndrome Ofdi Ofdsi Orofaciodigital Syndrome, Type I
Syringomyelia	Hydromyelia
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Bone Structure Disease
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10806	POC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POC5	RGD	RGD:1310597
Bos taurus	POC5	VGNC	VGNC:33100
Mus musculus	POC5	MGD	MGI:1914713
Canis familiaris	POC5	VGNC	VGNC:44762
Felis catus	POC5	VGNC	VGNC:64272
Macaca mulatta	POC5	VGNC	VGNC:76119
Others	POC5	NCBI