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SNX4 - sorting nexin 4 Gene

Also Known as ATG24B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8723

About SNX4

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:125,446,650-125,520,202 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 29.2), kidney (RPKM 26.4) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the Leptin receptor and with Receptor Tyrosine Kinases for platelet-derived growth factor, Insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

SNX4 Products (1)

mRNA	Protein	Name
NM_003794.4	NP_003785.1	sorting nexin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables insulin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables leptin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables phosphatidylinositol binding	IMP IMP: Inferred from mutant phenotype	17994011	GOA
enables phosphatidylinositol-3-phosphate binding	IMP IMP: Inferred from mutant phenotype	33468622	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9819414	GOA
enables transferrin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	17994011	GOA
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	32513819	GOA
involved in positive regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	17994011	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	18253931	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11279102	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	17994011	GOA
is active in early endosome	IDA IDA: Inferred from direct assay	32513819	GOA
is active in early endosome membrane	IDA IDA: Inferred from direct assay	33468622	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	17994011	GOA
located in membrane	IDA IDA: Inferred from direct assay	9819414	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18253931	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	9819414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX4 Protein Structure

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
sorting nexin-4

SNX4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX4	O95219	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	SNX4	O95219	MAGEA6	Homo sapiens	P43360	Y2H Array	25416956
Intra	SNX4	O95219	SNX7	Homo sapiens	Q9UNH6-3	Validated Y2H	32296183
Intra	SNX4	O95219	SNX7	Homo sapiens	Q9UNH6-3	Y2H Array	32296183
Intra	SNX4	O95219	SNX7	Homo sapiens	Q9UNH6-3	Y2H Prey Pooling	32296183
Intra	SNX4	O95219	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	SNX4	O95219	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	SNX4	O95219	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	SNX4	O95219	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
Intra	SNX4	O95219	BIN1	Homo sapiens	O00499	Y2H	12668730
Intra	SNX4	O95219	BIN1	Homo sapiens	O00499	Anti Bait CoIP	12668730
Intra	SNX4	O95219	SNX7	Homo sapiens	Q9UNH6	Anti Tag CoIP	35271311
Intra	SNX4	O95219	SNX30	Homo sapiens	Q5VWJ9	Pull Down	23085988
Intra	SNX4	O95219	SNX30	Homo sapiens	Q5VWJ9	Anti Tag CoIP	35271311
Intra	SNX4	O95219	SNX30	Homo sapiens	Q5VWJ9	Anti Tag CoIP	28514442
Intra	SNX4	O95219	SNX30	Homo sapiens	Q5VWJ9	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13543	SNX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNX4	VGNC	VGNC:35111
Mus musculus	SNX4	MGD	MGI:1916400
Rattus norvegicus	SNX4	RGD	RGD:1309763
Macaca mulatta	SNX4	VGNC	VGNC:77684
Canis familiaris	SNX4	VGNC	VGNC:46641
Felis catus	SNX4	VGNC	VGNC:65557
Others	SNX4	NCBI