SNX7 - sorting nexin 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51375

About SNX7

Cytogenetic location: 1p21.3 Genomic coordinates (GRCh38): 1:98,661,319-98,760,500 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 15 paralogues. Ubiquitous expression in colon (RPKM 10.6), small intestine (RPKM 8.3) and 24 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]

SNX7 Products (3)

mRNA Protein Name
NM_001364903.1 NP_001351832.1 sorting nexin-7 isoform c
NM_015976.5 NP_057060.2 sorting nexin-7 isoform a
NM_152238.4 NP_689424.2 sorting nexin-7 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
32513819 GOA
involved in protein transport IMP
IMP: Inferred from mutant phenotype
32513819 GOA
Cellular Component GO Annotation Evidence References Source
is active in early endosome IDA
IDA: Inferred from direct assay
32513819 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX7 Protein Structure

PX

PX: PX domain (99 - 210)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 451 a.a.
Protein Preferred Names Protein Names

sorting nexin-7

SNX7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNX7 Q9UNH6 SNX4 Homo sapiens O95219
Anti Tag CoIP
35271311
Intra
SNX7 Q9UNH6 SNX4 Homo sapiens O95219
Pull Down
23085988
Intra
SNX7 Q9UNH6 SNX4 Homo sapiens O95219
Anti Tag CoIP
33961781
Intra
SNX7 Q9UNH6 HGS Homo sapiens O14964
Y2H Array
25416956
Intra
SNX7 Q9UNH6 TEX11 Homo sapiens Q8IYF3
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153596 SNX7 Inhibitor 99.89% Unkown
HY-RS13546 SNX7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SNX7 VGNC VGNC:80362
Rattus norvegicus SNX7 RGD RGD:1305480
Canis familiaris SNX7 VGNC VGNC:46643
Bos taurus SNX7 VGNC VGNC:35113
Mus musculus SNX7 MGD MGI:1923811
Macaca mulatta SNX7 VGNC VGNC:106500
Others SNX7 NCBI