TOMM22 - translocase of outer mitochondrial membrane 22 Gene

Also Known as 1C9-2; TOM22; MST065; MSTP065

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56993

About TOMM22

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,681,957-38,685,421 (from NCBI)

This gene has 2 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in colon (RPKM 24.2), kidney (RPKM 23.3) and 25 other tissues.

Summary

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several Other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

TOMM22 Products (1)

mRNA Protein Name
NM_020243.5 NP_064628.1 mitochondrial import receptor subunit TOM22 homolog

TOMM22 Protein Structure

Tom22

Tom22: Mitochondrial import receptor subunit Tom22 (24 - 117)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

mitochondrial import receptor subunit TOM22 homolog

  • mitochondrial import receptor Tom22

TOMM22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TOMM22 Q9NS69 TOMM7 Homo sapiens Q9P0U1 12198123
Intra
TOMM22 Q9NS69 AQP6 Homo sapiens Q13520 32296183
Intra
TOMM22 Q9NS69 AQP6 Homo sapiens Q13520 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TOMM22 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82366 TOMM22 Antibody (YA2111) WB, IHC-P, ICC/IF, IP, FC Human

Related Diseases

Diseases Alias
3-Methylglutaconic Aciduria, Type V
  • 3-Methylglutaconic Aciduria Type 5

  • Mga5

  • MGCA5

  • Dcma

  • Dcma Syndrome

  • Dilated Cardiomyopathy With Ataxia

  • 3-Methylglutaconic Aciduria Type V

  • Mga Type V

  • Cardiomyopathy, Dilated, With Ataxia

  • Mga, Type V

  • Dilated Cardiomyopathy With Ataxia Syndrome

  • Dnajc19 Defect

  • 3-Methylglutaconic Aciduria 5

  • 3-Alpha-Methylglutaconic Aciduria Type 5

  • 3-@Methylglutaconic Aciduria, Type V

3-Methylglutaconic Aciduria, Type Iii
  • Optic Atrophy

  • 3-Methylglutaconic Aciduria Type 3

  • Costeff Syndrome

  • Mga3

  • Costeff Optic Atrophy Syndrome

  • Optic Atrophy Plus Syndrome

  • Infantile Optic Atrophy With Chorea And Spastic Paraplegia

  • 3-Methylglutaconic Aciduria Type Iii

  • Autosomal Recessive Optic Atrophy Plus Syndrome

  • Autosomal Recessive Optic Atrophy Type 3

  • Opa3 Defect

  • MGCA3

  • Mga, Type Iii

  • Iraqi Jewish Optic Atrophy Plus

  • Mga Type Iii

  • Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

  • Iraqi-Jewish 'Optic Atrophy Plus'

  • Optic Atrophy 3, Autosomal Recessive

  • Opa3, Autosomal Recessive

  • Opa3-Related 3-Methylglutaconic Aciduria

  • Iraqi-Jewish Optic Atrophy Plus

  • Atrophy Of Optic Disc

  • 3-Alpha Methylglutaconic Aciduria Type Iii

  • Optic Atrophy 3

  • Optic Atrophy Infantile With Chorea And Spastic Paraplegia

  • Autosomal Recessive Opa3

  • Autosomal Recessive Optic Atrophy 3

  • 3-Methylglutaconic Aciduria 3

  • 3-Alpha-Methylglutaconic Aciduria Type 3

  • Optic Atrophy 3 Autosomal Recessive

  • Atrophy, Optic

  • Atrophy, Optic, Plus Syndrome

  • Optic Nerve Atrophy

  • Primary Optic Atrophy

  • Oa - [Optic Atrophy]

  • Second Cranial Nerve Atrophy

  • Second Cranium Nerve Atrophy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus TOMM22 VGNC VGNC:49064
Felis catus TOMM22 VGNC VGNC:66443
Macaca mulatta TOMM22 VGNC VGNC:98461
Mus musculus TOMM22 MGD MGI:2450248
Rattus norvegicus TOMM22 RGD RGD:1303260
Others TOMM22 NCBI