TOMM7 - translocase of outer mitochondrial membrane 7 Gene

Also Known as TOM7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54543

About TOMM7

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:22,812,974-22,822,849 (from NCBI)

This gene has 6 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in ovary (RPKM 141.3), fat (RPKM 120.2) and 25 other tissues.

Summary

This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]

TOMM7 Products (1)

mRNA Protein Name
NM_019059.5 NP_061932.1 mitochondrial import receptor subunit TOM7 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12198123 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
24270810 GOA
involved in positive regulation of type 2 mitophagy IMP
IMP: Inferred from mutant phenotype
24270810 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
24270810 GOA
Cellular Component GO Annotation Evidence References Source
part of mitochondrial outer membrane translocase complex IDA
IDA: Inferred from direct assay
12198123 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
12198123 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOMM7 Protein Structure

Tom7

Tom7: TOM7 family (9 - 53)

  • 0
  • 55 a.a.
Protein Preferred Names Protein Names

mitochondrial import receptor subunit TOM7 homolog

  • translocase of outer membrane 7 kDa subunit homolog

TOMM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TOMM7 Q9P0U1 TOMM22 Homo sapiens Q9NS69
BN-PAGE
12198123
Intra
TOMM7 Q9P0U1 TOMM20 Homo sapiens Q15388
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
3-Methylglutaconic Aciduria, Type Iii

  • Optic Atrophy

  • 3-Methylglutaconic Aciduria Type 3

  • Costeff Syndrome

  • Mga3

  • Costeff Optic Atrophy Syndrome

  • Optic Atrophy Plus Syndrome

  • Infantile Optic Atrophy With Chorea And Spastic Paraplegia

  • 3-Methylglutaconic Aciduria Type Iii

  • Autosomal Recessive Optic Atrophy Plus Syndrome

  • Autosomal Recessive Optic Atrophy Type 3

  • Opa3 Defect

  • MGCA3

  • Mga, Type Iii

  • Iraqi Jewish Optic Atrophy Plus

  • Mga Type Iii

  • Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

  • Iraqi-Jewish 'Optic Atrophy Plus'

  • Optic Atrophy 3, Autosomal Recessive

  • Opa3, Autosomal Recessive

  • Opa3-Related 3-Methylglutaconic Aciduria

  • Iraqi-Jewish Optic Atrophy Plus

  • Atrophy Of Optic Disc

  • 3-Alpha Methylglutaconic Aciduria Type Iii

  • Optic Atrophy 3

  • Optic Atrophy Infantile With Chorea And Spastic Paraplegia

  • Autosomal Recessive Opa3

  • Autosomal Recessive Optic Atrophy 3

  • 3-Methylglutaconic Aciduria 3

  • 3-Alpha-Methylglutaconic Aciduria Type 3

  • Optic Atrophy 3 Autosomal Recessive

  • Atrophy, Optic

  • Atrophy, Optic, Plus Syndrome

  • Optic Nerve Atrophy

  • Primary Optic Atrophy

  • Oa - [Optic Atrophy]

  • Second Cranial Nerve Atrophy

  • Second Cranium Nerve Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14886 TOMM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22871 Tomm7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29385 Tomm7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TOMM7 MGD MGI:1913419
Felis catus TOMM7 VGNC VGNC:102724
Canis familiaris TOMM7 VGNC VGNC:54798
Macaca mulatta TOMM7 VGNC VGNC:108450
Rattus norvegicus TOMM7 RGD RGD:1591393
Others TOMM7 NCBI